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Here are the 10 supplements I take while on my Zepbound weight loss journey

Trisha Easto
Paste BN
April 10, 2025Updated Feb. 23, 2026, 12:21 p.m. ET
Supplements go hand-in-hand with my GLP-1 injection
  • The author supplements GLP-1 medication with vitamins and gummies to combat side effects and support overall health.
  • Supplements mentioned include fiber, digestive enzymes, vitamins D and B12, collagen, magnesium, protein shakes and electrolytes.
  • The author recommends consulting a doctor before taking new supplements in conjunction with weight loss medications.

Weight loss injections like Ozempic and Zepbound have taken Hollywood and social media by storm over the last year or so. Personally, I've been on Zepbound for the last year and I've lost over 70 pounds thanks to a combination of the injection, diet, exercise and, of course, the advice of my doctor. One of the things I learned early on was the importance of supplementing my daily diet with vitamins and gummies in order to help prevent some of the not-so-fun side effects of GLP-1 medications.

Focusing on protein is a huge part of my nutrition and even calorie and macro counting, but it's also to help maintain muscle mass. Drinking a protein shake before the injection helps me alleviate any nausea. I also keep a rotation of daily vitamins and supplements, like vitamin D and collagen to combat hair loss that can occur when you lose weight, fiber gummies to keep things moving (literally) and more.

Seriously, my supplement shelf is starting to look like a pharmacy, but I won't gate keep. Below, take a look at the vitamins and supplements that I have added to my daily routine to help keep me feeling my best while taking a GLP-1.

Note: This is not medical advice. Every weight loss journey is different and we suggest consulting your doctor before starting any weight loss medications or taking vitamins and supplements.

My favorite supplements while taking a GLP-1

1. A solid multi-vitamin

NatureMade multi-vitamin for her
One of the ways GLP-1's work is by suppressing your appetite, taking in less food means taking in less of the good stuff too, so the multi-vitamin helps put some back. Buy at Amazon

💊 Pro-tip: If you're unsure of making health and wellness-related purchases on Amazon, be sure to check the seller and make sure it's coming from a brand's official storefront, like NatureMade.

2. Fiber gummies

VitaFusion's Fiber Well gummies
Depending on your age and gender, you could need anywhere from 25 to 40g of fiber daily. These gummies give you an added boost on days you might be off-target. Buy at Sam's Club

🍫 I stock up on these FiberOne Oats & Chocolate bars which have 9g of fiber per bar, but you can also try the chocolate brownie for a sweet treat in the evenings—the brownies taste best after a couple seconds in the microwave!

3. Digestive enzymes

California Gold Nutrition, Digestive Enzymes
Another way GLP-1's work is by slowing down the digestion process, making you feel fuller longer, but it also means you could be dealing with constipation. Buy at iHerb

4. Vitamin D

California Gold Nutrition, Vitamin D3
Vitamin D is essential in the absorption of calcium and bone health, making it a perfect addition to your GLP-1 supplements. Buy at iHerb

5. Vitamin B12

21st Century, B-12, 500 mcg
Fatigue is a common side effect on GLP-1 medications, but you can fight that without the need for energy drinks by adding B12 into your supplement routine. Buy at iHerb

6. Collagen

Youtheory Collagen tablets
When I started losing weight, I also starting losing hair. Enter collagen. A tasteless powder is tolerable, but this capsule form is just top tier to add to my daily supplements. Buy at iHerb

7. Omega-3

California Gold Nutrition, Omega-3, Premium Fish Oil
This one isn't necessarily related to my GLP-1 use, but I take an Omega-3 or Fish Oil daily to help lower triglycerides. Buy at iHerb

8. Magnesium

Nature Made Magnesium Oxide Softgels
Magnesium comes in many forms with just as many benefits, including helping to regulate your digestive system. But, I'm actually on it to promote better sleep and combat regular migraines. Buy at iHerb

9. Protein shakes

Core Power Elite High Protein Strawberry Shake
If you lose weight rapdily, you could also be at risk for losing muscle mass, so you should aim to get plenty of protein in, which is not easy when you don't have an appetite so this protein shake is a quick fix with 42g! Buy at Amazon

🏋️ Pro-tip: Calculate the exact amount of calories you need, including a breakdown of macros like the grams of protein you should aim for everyday with a TDEE calculator.

10. Electrolytes

IV Liquid Electrolytes Variety Pack
GLP-1's increase your fluid loss, which can lead to dehydration and make fatigue worse, so it's important to take in electrolytes daily. Buy at Amazon

What are GLP-1's?

GLP-1's are a category of prescription medications labeled as glucagon-like peptide-1's. They're offered in several brand name forms, like Ozempic, where semaglutide is the main substance, or Zepbound, where tirzepatide is the main substance. But they do basically the same thing. They mimic a hormone that the body is supposed to produce naturally, which increases the amount of insulin released by the pancreas in order to control blood sugar. While they were initially created to control diabetes, they have been proven to be effective tools for weight loss.

How can I get on a GLP-1?

GLP-1's are a prescription medication, so you'll need to talk to your doctor. In some cases, a GLP-1 can be prescribed by your doctor and covered by your insurance (be sure to check with your provider on specific coverage details). But, there are options for you online. Consulting a medical professional online is available in some states through Hims and Hers for men and women.

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