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Skin & Nail Care

Shop new Perricone MD neuropeptide anti-aging drop with luxury gifts

New Perricone MD Neuropeptide Deep Crease & Eyelid Lift Serums offers professional-level anti-aging results—plus exclusive gift sets.

Shop Perricone MD's new neuropeptide collection for visibly smoother, brighter skin.
Jan. 13, 2026Updated Jan. 17, 2026, 8:10 a.m. ET
  • Perricone MD has launched a new neuropeptide skincare collection designed to address signs of aging.
  • The brand is offering a free Gua Sha tool with the purchase of its Deep Crease Serum for a limited time.
  • Customers who buy any two Perricone MD products will receive a complimentary Gold Cosmetic Bag.

Perricone MD is elevating high-performance skincare with the most recent launch of its neuropeptide collection. To kick off 2026, the new lineup is designed to visibly smooth, refine and rejuvenate the look of aging skin.

Plus, the premium beauty brand is offering extra gifts that'll turn your next skincare purchase into an investment in luxury. For a limited-time, shoppers get a free Gua Sha sculpting tool with the purchase of the Neuropeptide Deep Crease Serum.

Additionally, with the purchase of any two Perricone MD products, shoppers will get a Gold Cosmetic Bag, ideal for storing skincare essentials or traveling in style.

Whether you're refreshing your skincare routine or searching for a truly luxe gift, Perricone MD's neuropeptide essentials deliver visible results and skincare indulgence.

Here's a breakdown of Perricone MD's neuropeptide skincare collection.

Get Perricone MD's neuropeptide skincare

Shop Perricone MD's neuropeptide skincare lineup

1. Neuropeptide Deep Crease Serum

Neuropeptide Deep Crease Serum
This highly-potent, silky serum helps smooth skin and reduce deep lines, wrinkles and creases around the mouth, eyes, lips and forehead. Get now at Perricone MD
  • 84% agreed it smooths wrinkles
  • 83% agreed skin looks and feels firmer
  • 77% agreed creases appear shallower

2. Pore-Refining & Resurfacing Cream Cleanser

Neuropeptide Pore-Refining & Resurfacing Cream Cleanser
This triple action creamy cleanser gently exfoliates and works to unclog pores. It also works to retexturize skin by removing dead surface cells for smoother and healthier skin. Get now at Perricone MD

3. The Cleansing Balm

Neuropeptide The Cleansing Balm
This cleansing balm is non-greasy and works to clean away dirt, debris, excess oil and makeup. It also offers nourishment for softer, more radiant skin. Get now at Perricone MD

4. Rejuvenating Moisturizer SPF 25

Neuropeptide Rejuvenating Moisturizer SPF 25
This rejuvenating moisturizer is packed with nutrients and has a balm-like texture to deeply moisturize skin. It's also formulated with mineral-based sun protection. Get now at Perricone MD

5. Pro-Strength Firming Moisturizer

Neuropeptide Pro-Strength Firming Moisturizer
Need a luxurious moisturizer? Get this pro-strength firming moisturizer that'll nourish skin. It'll also improve skin's thickness, firmness and plumpness. Get now at Perricone MD

6. Eyelid Lift Serum

Neuropeptide Eyelid Lift Serum
Tired of eyelid creases? This ultra-lightweight serum has a fast-absorbing texture to reduce the look of drooping, sagging lids. Get now at Perricone MD

7. Corrective Brightening Under-Eye Cream

Neuropeptide Corrective Brightening Under-Eye Cream
Get rid of under-eye darkness, puffiness and deep lines with this silky eye cream. It works to correct severe dark circles, crow's feet and bags for smoother and brighter skin. Get now at Perricone MD
Shop the full neuropeptide collection

What are neuropeptides?

Visible smoothing of deep lines and creases after consistent use of Perricone MD’s Neuropeptide Deep Crease Serum.

Neuropeptides are small, protein-like molecules made of short amino acid chains. They're used by neurons to act as chemical messengers to communicate with each other and other tissues throughout the body.

What are the benefits of neuropeptides in skincare?

Neuropeptides are gaining popularity in skincare for their topical benefits including diminishing deep wrinkles, improving skin's firmness and stimulating collagen production.

Does Perricone MD have a rewards program?

Yes, Perricone MD has an exclusive loyalty program called Perricone Plus+ Rewards, where shoppers can earn points on purchases. Plus, members get perks like birthday gifts, early sale access and exclusive offers by creating and signing into their account.

Perricone Plus+ Rewards
Join Perricone Plus+ Rewards today to get early sale access and exclusive offers. Join Perricone Plus+ Rewards

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