Louisville vs Creighton predictions, game picks for 2025 NCAA Tournament first round
It's Louisville vs Creighton in the 2025 NCAA Tournament first round. See our expert picks and predictions for the March Madness bracket, along with betting odds and game time.
The 2025 NCAA Tournament is here, folks.
Kicking off the first round on Thursday will be a South Region matchup of Louisville vs. Creighton.
The Louisville Cardinals finished the 2024-25 season with a 27-7 record, good for third in the ACC. That earned them a No. 8 seed in the 2025 March Madness bracket. Their opponent, the Creighton Bluejays, finished second in the Big East with a 24-10 record. That earned them a No. 9 seed in the Big Dance.
Louisville ranks as the 23rd-best team in the KenPom rankings, sporting the 29th-best offense and 21st-best defense. Meanwhile, Creighton ranks 37th overall, possessing the 34th-ranked offense and 42nd-ranked defense.
Here's how our experts see Thursday's Round of 64 clash playing out. Be sure to check out Paste BN's complete March Madness bracket predictions to see our team's picks for every game. While you're at it, don't forget to read our tournament bold predictions and upset picks.
Without further ado, here's our Louisville vs. Creighton picks and predictions.
Louisville vs. Creighton picks and predictions
- Jordan Mendoza: Louisville
- Paul Myerberg: Creighton
- Erick Smith: Louisville
- Eddie Timanus: Creighton
- Dan Wolken: Louisville
- Craig Meyer: Creighton 74, Louisville 72
- Brooks Holton: Louisville 72, Creighton 68
Our experts are fairly divided in this contest, with four opting for Louisville and the other three going with Creighton. Craig Meyer has the underdog Bluejays winning outright and just barely going over the 145.5-point total. The Courier Journal's Brooks Holton has the Cardinals covering the 2.5-point spread and the total going under.
Louisville vs. Creighton date, start time, how to watch
- Game Day: Thursday, March 20, 2025
- Game Time: 12:15 p.m. ET
- Location: Rupp Arena in Lexington, Kentucky
- TV Channel: CBS
- Live Stream: Fubo - Watch Now!
Watch Louisville vs. Creighton on Fubo
Louisville vs. Creighton odds
Odds as of Tuesday, March 18 via BetMGM.
- Spread: Louisville -2.5 (-110)
- Moneyline Favorite: Louisville -145
- Moneyline Underdog: Creighton +120
- Total: 145.5
March Madness game-by-game predictions for Thursday
- Creighton vs Louisville prediction, picks
- High Point vs Purdue prediction, picks
- Montana vs Wisconsin prediction, picks
- SIU Edwardsville vs Houston prediction, picks
- Alabama St. vs Auburn prediction, picks
- McNeese vs. Clemson prediction, picks
- VCU vs BYU prediction, picks
- Georgia vs Gonzaga prediction, picks
- Wofford vs Tennessee prediction, picks
- Arkansas vs Kansas prediction, picks
- Yale vs Texas A&M prediction, picks
- Drake vs Missouri prediction, picks
- Utah St. vs UCLA prediction, picks
- Nebraska Omaha vs St. John's prediction, picks
- UCSD vs Michigan prediction, picks
- N.C. Wilmington vs Texas Tech prediction, pick
We occasionally recommend interesting products and services. If you make a purchase by clicking one of the links, we may earn an affiliate fee. Paste BN Network newsrooms operate independently, and this doesn’t influence our coverage.