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Duke vs. Mount St. Mary's prediction, picks for 2025 men's NCAA Tournament


It's Duke vs Mount St. Mary's in the 2025 NCAA Tournament first round. See our expert picks and predictions for the March Madness bracket, along with game time and how to watch.

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Editor's note: Follow Men's March Madness live updates and scores from Friday's first-round action.

The men's 2025 NCAA Tournament is underway for college basketball fans everywhere.

First-round action continues Friday with an East Region matchup between Duke and Mount St. Mary's in Raleigh, North Carolina.

The Duke Blue Devils and star Cooper Flagg finished the 2024-25 season with a 31-3 record, good for first in the ACC. That earned them a No. 1 seed in the 2025 March Madness bracket. Their opponent, the Mount St. Mary's Mountaineers, finished fourth in the MAAC regular-season standings with a 23-12 record and a conference tournament win earned them a No. 16 seed in the Big Dance. Mount St. Mary's beat American in a play-in game Wednesday to advance to the round of 64.

Duke is currently No. 1 overall in the KenPom rankings, with the third-best offense and fourth-best defense. Mount St. Mary's ranks 238th overall, possessing the 279th-ranked offense and 183rd-ranked defense.

Here's how our experts see Friday's Round of 64 clash playing out. Be sure to check out Paste BN's complete March Madness bracket predictions to see our team's picks for every game. And don't forget to read our tournament bold predictions and upset picks.

Is Duke's Cooper Flagg playing today?

Yes, Flagg is expected to play despite suffering an ankle injury.

Duke vs. Mount St. Mary's picks and score predictions

It's a clean sweep. None of our experts have this contest turning into an upset. Craig Meyer has Mount St. Mary's barely covering the 32.5-point spread, and he predicts the game to go over the 140.5-point total. The Fayetteville Observer's Rodd Baxley has Duke advancing past Mount St. Mary's.

Duke vs. Mount St. Mary's date, start time, how to watch

  • Game Day: Friday, March 21, 2025
  • Game Time: 2:50 p.m. ET
  • Location: Lenovo Center in Raleigh, North Carolina
  • TV Channel: CBS
  • Live Stream: Fubo (free trial)

Watch Duke vs. Mount St. Mary's with Fubo

Duke vs. Mount St. Mary's odds

Odds as of Thursday, March 20 via BetMGM.

  • Spread: Duke -32.5 (-105)
  • Moneyline Favorite: Duke -10000
  • Moneyline Underdog: Mount St. Mary's +3300
  • Total: 140.5

March Madness game-by-game predictions for Friday

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