Iowa State vs Lipscomb prediction, picks for 2025 men's NCAA Tournament
It's Iowa State vs Lipscomb in the 2025 NCAA Tournament first round. See our expert picks and predictions for the March Madness bracket, along with betting odds and game time.

Editor's note: Follow Men's March Madness live updates and scores from Friday's first-round action.
The 2025 NCAA Tournament is here, folks.
First-round action continues on Friday with a matchup between Iowa State and Lipscomb in the South Region.
The Iowa State Cyclones finished the 2024-25 season with a 24-9 record, good for fifth in the Big 12. That earned them a 3 seed in the 2025 March Madness bracket. Their opponent, the Lipscomb Bisons, finished first in the ASun with a 25-9 record and a conference tournament win earned them a No. 14 seed in the Big Dance.
Iowa State ranks as the 10th-best team in the KenPom rankings, sporting the 20th-best offense and ninth-best defense. Meanwhile, Lipscomb ranks 83rd overall, possessing the 75th-ranked offense and 100th-ranked defense.
Here's how our experts see Friday's Round of 64 clash playing out. Be sure to check out Paste BN's complete March Madness bracket predictions to see our team's picks for every game. While you're at it, don't forget to read our tournament bold predictions and upset picks.
Without further ado, here's our Iowa State vs. Lipscomb picks and predictions.
Iowa State vs. Lipscomb picks and predictions
- Jordan Mendoza: Iowa State
- Paul Myerberg: Iowa State
- Erick Smith: Iowa State
- Eddie Timanus: Iowa State
- Dan Wolken: Iowa State
- Craig Meyer: Iowa State 70, Lipscomb 59
- Mike Organ: Iowa State 71, Lipscomb 58
It's a clean sweep. None of our experts have this contest turning into an upset. Craig Meyer and The Tennessean's Mike Organ are both in agreement that Lipscomb will cover the 14.5-point spread and the game will go under the 143.5-point total.
Iowa State vs. Lipscomb date, start time, how to watch
- Game Day: Friday, March 21, 2025
- Game Time: 1:30 p.m. ET
- Location: Fiserv Forum in Milwaukee
- TV Channel: TNT
- Live Stream: Sling TV - Watch Now!
Watch Iowa State vs. Lipscomb on Sling TV
Iowa State vs. Lipscomb odds
Odds as of Wednesday, March 19 via BetMGM.
- Spread: Iowa State -14.5 (-110)
- Moneyline Favorite: Iowa State -1400
- Moneyline Underdog: Lipscomb +800
- Total: 143.5
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