Houston vs Purdue prediction, picks for 2025 men's NCAA Tournament Sweet 16
It's Houston vs Purdue in the 2025 NCAA Tournament Sweet 16. See our expert picks and predictions for the March Madness bracket, along with how to watch and game time.
The 2025 men's NCAA Tournament is in full swing. After starting with 68 teams, the field is down to 16. A Sweet 16, that is.
Tournament action continues with the Sweet 16 on Friday, with the final game of the round featuring a matchup between Houston and Purdue in the Midwest Region.
The Houston Cougars earned a No. 1 seed in the 2025 March Madness bracket. They knocked off the SIU Edwardsville Cougars in the first round and the Gonzaga Bulldogs in the Round of 32 to reach this point. Houston's opponent, the 4-seeded Purdue Boilermakers, defeated both the High Point Panthers and McNeese State Cowboys.
Houston ranks as the second-best team in the KenPom rankings, sporting the 10th-best offense and best defense. Meanwhile, Purdue ranks 16th overall with the seventh-ranked offense and 55th-ranked defense.
Here's how our experts see Friday's Sweet 16 clash playing out. Be sure to check out the complete March Madness Sweet 16 schedule, times and TV info.
Houston vs. Purdue picks and predictions
- Jeremy Cluff: Houston 68, Purdue 63
- Sportsbook Wire: Houston 74, Purdue 67
- Craig Meyer: Houston 69, Purdue 62
- Sam King: Houston 75, Purdue 64
It's a clean sweep. None of our experts are predicting an upset in this matchup. AZ Central's Jeremy Cluff and Paste BN's Craig Meyer are both backing Purdue to cover the 8.5-point spread and the under-132.5 point total. Lafayette Journal & Courier's Sam King is laying the points with Houston and taking the over.
Houston vs. Purdue date, start time, where to watch
- Game Day: Friday, March 28, 2025
- Game Time: 10:09 p.m. ET
- Location: Lucas Oil Stadium in Indianapolis, Indiana
- TV Channel: TBS
- Live Stream: Sling TV - Watch Now!
Watch Houston vs. Purdue on Sling TV
Houston vs. Purdue odds
Odds as of Wednesday, March 26 via BetMGM.
- Spread: Houston -8.5 (-105)
- Moneyline Favorite: Houston -400
- Moneyline Underdog: Purdue +300
- Total: 132.5
March Madness Sweet 16 game-by-game predictions
- Alabama vs. BYU predictions, picks
- Florida vs. Maryland predictions, picks
- Duke vs. Arizona predictions, picks
- Texas Tech vs. Arkansas predictions, picks
- Michigan State vs. Ole Miss predictions, picks
- Tennessee vs. Kentucky predictions, picks
- Auburn vs. Michigan predictions, picks
- Houston vs. Purdue predictions, picks
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