Michigan State vs Ole Miss prediction, picks for 2025 men's Sweet 16
It's Michigan State vs Ole Miss in the 2025 NCAA Tournament Sweet 16. See our expert picks and predictions for the March Madness bracket, along with how to watch and game time.
The 2025 men's NCAA Tournament is in full swing. After starting with 68 teams, the field is down to 16. A Sweet 16, that is.
Tournament action continues with the Sweet 16 on Friday, featuring a matchup between Michigan State and Ole Miss in the South Region.
The Michigan State Spartans earned a No. 2 seed in the 2025 March Madness bracket. They knocked off the Bryant Bulldogs in the first round and the New Mexico Lobos in the Round of 32 to reach this point. Michigan State's opponent, the 6-seeded Ole Miss Rebels, advanced after defeating both the North Carolina Tar Heels and Iowa State Cyclones.
Michigan State ranks as the seventh-best team in the KenPom rankings, sporting the 25th-best offense and fifth-best defense. Meanwhile, Ole Miss ranks 21st overall with the 24th-ranked offense and 21st-ranked defense.
Here's how our experts see Friday's Sweet 16 clash playing out. Be sure to check out the complete Sweet 16 schedule, times and TV info, as well as our power rankings.
Michigan State vs. Ole Miss Sweet 16 picks and predictions
- Jeremy Cluff: Ole Miss 74, Michigan State 69
- Craig Meyer: Ole Miss 71, Michigan State 67
- Sportsbook Wire: Michigan State 76, Ole Miss 72
- Sam Hutchens: Michigan State 79, Ole Miss 78
Our four experts are splits, with two backing the Ole Miss Rebels to pull off the upset. AZ Central's Jeremy Cluff and Paste BN's Craig Meyer are taking them to win outright along with the under 143.5-point total, while Sportsbook Wire and Clarion Ledger's Sam Hutchens laying the 3.5-point spread with Michigan State and taking the over.
Michigan State vs. Ole Miss date, start time, where to watch
- Game Day: Friday, March 28, 2025
- Game Time: 7:09 p.m. ET
- Location: State Farm Arena in Atlanta, Georgia
- TV Channel: CBS
- Live Stream: Fubo - Watch Now!
Watch Michigan State vs. Ole Miss on Fubo
Michigan State vs. Ole Miss odds
Odds as of Monday, March 24 via BetMGM.
- Spread: Michigan State -3.5 (-102)
- Moneyline Favorite: Michigan State -160
- Moneyline Underdog: Ole Miss +135
- Total: 143.5
March Madness Sweet 16 game-by-game predictions
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- Florida vs. Maryland predictions, picks
- Duke vs. Arizona predictions, picks
- Texas Tech vs. Arkansas predictions, picks
- Michigan State vs. Ole Miss predictions, picks
- Tennessee vs. Kentucky predictions, picks
- Auburn vs. Michigan predictions, picks
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