Duke vs. Houston prediction, picks for 2025 men's NCAA Tournament Final Four
A true clash of powers will happen in the men's 2025 Final Four.
The second game to take place inside the Alamodome Saturday will feature No. 1 Duke vs. No. 1 Houston. Both teams had impressive runs to the Final Four, with the Blue Devils dominating every team they faced in the NCAA Tournament while the Cougars had to face the best seed possible in every game.
In terms of metrics, Duke and Houston are the top teams in college basketball. In KenPom, Duke is No. 1 and Houston is No. 2. The Blue Devils have the top offensive rating as their 83.7 points per game is top 10 in the country, while the Cougars have the best defensive rating, with the top scoring defense in the country at 58.3 points allowed per game. Will it be the Duke offense or the Houston defense that leads their teams to the national championship game?
Here are picks and the betting odds for Saturday's Final Four showdown.
Duke vs. Houston picks and predictions
- Jordan Mendoza: Houston beats Duke
- Blake Toppmeyer: Houston beats Duke
- Tony Garcia: Duke beats Houston
- Jeremy Cluff: Duke 70, Houston 64
The early verdict is split among Paste BN Network picks. Garcia of the Detroit Free Press predicted prior to the Elite Eight that Duke would defeat Houston, and Cluff of AZ Central predicts Duke to beat the Cougars by six points.
Duke vs. Houston date, start time, where to watch
- Game Day: Saturday, April 5, 2025
- Game Time: 8:49 p.m. ET
- Location: Alamodome in San Antonio, Texas
- TV Channel: CBS
- Live Stream: Fubo
Watch Duke vs. Houston Final Four on Fubo
Duke vs. Houston odds
Odds as of Monday, March 31 via BetMGM.
- Spread: Duke -4.5 (-110)
- Moneyline Favorite: Duke -210
- Moneyline Underdog: Houston +170
- Total: 136.5