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Louisville vs. Nebraska prediction, picks for 2025 women's NCAA Tournament


It's Louisville vs. Nebraska in the 2025 NCAA Tournament first round. See our expert picks and predictions for the women's March Madness bracket, along with betting odds and game time.

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Editor's note: Follow Women's March Madness live updates and scores from Friday's first-round action.

The 2025 NCAA women's tournament is here, folks.

Among the first-round action Friday night will be a matchup between Louisville and Nebraska.

The Louisville Cardinals finished the 2024-25 season with a 21-10 record, good for sixth in the ACC. That earned them a 7 seed in the 2025 women's March Madness bracket. Their opponent, the Nebraska Cornhuskers, were 21-11 and found themselves as a 10 seed.

Louisville is ranked 32nd in the country in efficiency by Barttorvik, while Nebraska (39th overall) ranks 13th in offensive efficiency.

Here's how our experts see Friday's Round of 64 clash playing out. Be sure to check out Paste BN's complete March Madness bracket breakdown for in-depth analysis. While you're at it, don't forget to read our tournament upset picks and players who could make a splash.

Without further ado, here are our Louisville vs. Nebraska picks and predictions.

Louisville vs. Nebraska picks and predictions

Our experts from across the Paste BN Network are leaning one way (7-2) on who will win this game,  No. 7 seed Louisville or No. 10 seed Nebraska. The Cardinals do have a slight edge in efficiency statistics. Take a look at their full bracket predictions.

  • Nancy Armour, Paste BN: Nebraska
  • Jordan Mendoza, Paste BN: Louisville
  • Cydney Henderson, Paste BN: Louisville
  • Meg L. Hall, For The Win: Louisville
  • Cora Hall, Knoxville News: Louisville
  • Liam Rooney, Tallahassee Democrat: Louisville
  • Cory Diaz, The Daily Advertiser: Louisville
  • Tom Noie, South Bend Tribune: Nebraska
  • Alexis Cubit, Louisville Courier Journal: Louisville 76, Nebraska 70

Cubit writes in the Courier-Journal: "The Cardinals' upperclassmen still have a sour taste in their mouths from losing in the first round of last year's NCAA Tournament, the first time it's happened in program history. Their leadership and the youthful talent and energy will be enough to get U of L to the second round."

Louisville vs. Nebraska date, start time, how to watch

  • Game Day: Friday, March 21, 2025
  • Game Time: 6 p.m. ET
  • Location: Ed and Rae Schollmaier Arena in Fort Worth, Texas
  • TV Channel: ESPN
  • Live Stream: Fubo - Watch Now!

Watch Louisville vs. Nebraska on Fubo

Louisville vs. Nebraska odds

Odds via BetMGM as of Wednesday, March 19.

  • Spread: Louisville -2.5
  • Moneyline Favorite: Louisville -155
  • Moneyline Underdog: Nebraska +130
  • Total: 146.5

Women's March Madness game-by-game predictions for Friday

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