Jacksonville Jaguars at Indianapolis Colts: Predictions, picks and odds for NFL Week 6 matchup
Already playing one another for the second time in six weeks, Trevor Lawrence and the Jacksonville Jaguars travel to Indianapolis to take on Matt Ryan's Colts in a pivotal AFC South matchup.
The Jaguars (2-3) dominated the Colts in their matchup earlier this season, but will the Colts (2-2-1) even the season series at home? Lawrence, Christian Kirk and the Jaguars are on the heels of a crushing loss to the Houston Texans, while Indianapolis is coming off an ugly win in Denver against the Broncos. The game is set to kick off Sunday at 1 p.m. ET from Lucas Oil Stadium.
Here's a look at the betting details and Paste BN's NFL staff picks for the Jaguars vs. Colts Week 6 game:
Jaguars at Colts odds, moneyline and over/under
- Spread: Colts (-1.5)
- Moneyline: Colts (-125); Jaguars (-105)
- Over/under: 41.5
- More odds, injury info for Jaguars vs. Colts
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NFL Week 6 odds, predictions and picks
Commanders vs. Bears | Patriots vs. Browns | Buccaneers vs. Steelers | Ravens vs. Giants | Vikings vs. Dolphins | Jets vs. Packers | 49ers vs. Falcons | Bengals vs. Saints | Jaguars vs. Colts | Cardinals vs. Seahawks | Panthers vs. Rams | Bills vs. Chiefs | Cowboys vs. Eagles | Broncos vs. Chargers
Lorenzo Reyes: Jaguars 17, Colts 14
While the Jaguars have struggled over the last two weeks, their early-season success showed they can be competitive. The key is limiting turnovers and putting Trevor Lawrence in a spot to get the ball out quickly. The Colts have so many issues: turnover margin (-6), offensive line (tied for league-high 21 sacks allowed). They may win this game straight up. I don’t think they can cover.
Safid Deen: Jaguars 21, Colts 17
The Jaguars had a frustrating loss to the Texans last week, but Indianapolis has one of the league’s worst offenses. Give me Jacksonville on the road.
Lance Pugmire: Jaguars 20, Colts 17
This is the most unpredictable game on the board as the Jaguars have floundered since their impressive Week 3 triumph at the Chargers and the Colts’ offense – even with this week’s return of Jonathan Taylor – has been a punchline.
Jarrett Bell: Jaguars 20, Colts 19
Nate Davis: Colts 23, Jaguars, 20
Tyler Dragon: Jaguars 23, Colts 16
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