San Francisco 49ers at Atlanta Falcons: Predictions, picks and odds for NFL Week 6 matchup

Can Jimmy Garoppolo and San Francisco 49ers (3-2) pick up a win on the road when they visit Marcus Mariota's Atlanta Falcons (2-3)?
The 49ers look for a win to increase their standing in what has turned out to be a wide-open NFC West division, while the Falcons rebound after a controversial roughing-the-passer call denied them a chance to vie for a Week 4 win against the Tampa Bay Buccaneers. The game is set to kick off Sunday at 1 p.m. ET from Mercedes-Benz Stadium.
Here's a look at the betting details and Paste BN's NFL staff picks for the 49ers vs. Falcons Week 6 game:
49ers at Falcons odds, moneyline and over/under
- Spread: 49ers (-4.5)
- Moneyline: 49ers (-220); Falcons (+180)
- Over/under: 45.5
- More odds, injury info for 49ers vs. Falcons
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NFL Week 6 odds, predictions and picks
Commanders vs. Bears | Patriots vs. Browns | Buccaneers vs. Steelers | Ravens vs. Giants | Vikings vs. Dolphins | Jets vs. Packers | 49ers vs. Falcons | Bengals vs. Saints | Jaguars vs. Colts | Cardinals vs. Seahawks | Panthers vs. Rams | Bills vs. Chiefs | Cowboys vs. Eagles | Broncos vs. Chargers
Lorenzo Reyes: 49ers 24, Falcons 17
The Falcons are a perfect 5-0 against the spread this season, the only unblemished team in the NFL. Still, I find them to be a risky play, depending on the matchup. This is one, with San Francisco’s defense being elite, where I don’t have confidence in Atlanta keeping that trend alive. The key for the Niners is to get Good Jimmy Garoppolo and not Bad Jimmy Garoppolo.
Safid Deen: 49ers 23, Falcons 20
San Francisco’s defense takes advantage of another lowly offense this week to win their third straight game. It’s about time we consider the 49ers as a threat to make the NFC title game again this season.
Lance Pugmire: 49ers 30, Falcons 10
Despite some injuries, San Francisco is finding its defensive footing — no opponent has scored more than 20 points yet — and it’s difficult to envision the undermanned hosts causing problems for the unit.
Jarrett Bell: 49ers 27, Falcons 23
Nate Davis: 49ers 27, Falcons 23
Tyler Dragon: 49ers 26, Falcons 16
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