San Francisco 49ers at Arizona Cardinals: Predictions, picks and odds for NFL Week 11 matchup
The NFL heads south of the border when quarterback Jimmy Garoppolo and the San Francisco 49ers (5-4) take on DeAndre Hopkins' Arizona Cardinals (4-6).
The Cardinals likely wish they were on a bye week instead of a business trip to Mexico given their mess of injuries — including ailments to Kyler Murray and Zach Ertz. Meanwhile, the 49ers are fresh off a win over the Los Angeles Chargers. Can Garoppolo, Christian McCaffrey, Deebo Samuel, George Kittle and the San Francisco offense keep it going in a pivotal NFC West bout? The game kicks off Monday at 8:15 p.m. ET from Estadio Azteca in Mexico City,
Here's a look at the betting details and Paste BN's NFL staff picks for the 49ers vs. Cardinals Week 11 game:
49ers at Cardinals odds, moneyline and over/under
- Spread: 49ers (-8)
- Moneyline: 49ers (-370); Cardinals (+300)
- Over/under: 43.5
- More odds, injury info for 49ers vs. Cardinals
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NFL Week 11 odds, predictions and picks
Titans vs. Packers | Panthers vs. Ravens | Bears vs. Falcons | Eagles vs. Colts | Jets vs. Patriots | Lions vs. Giants | Commanders vs. Texans | Browns vs. Bills | Rams vs. Saints | Raiders vs. Broncos | Bengals vs. Steelers | Cowboys vs. Vikings | Chiefs vs. Chargers | 49ers vs. Cardinals
Lorenzo Reyes: 49ers 25, Cardinals 23
This is another really interesting matchup, especially with it being in Mexico City. Arizona’s offense looked steadier with Colt McCoy under center. I still want to see more of a sample size before going all-in on the Cardinals being a solid play. Still, San Francisco has been an iffy play, failing to cover three of its last four.
Safid Deen: 49ers 27, Cardinals 23
The Cardinals took advantage of a wounded Rams' team last week, but won’t have the same luck against the loaded San Francisco 49ers. This should be a fun one in Mexico City.
Lance Pugmire: 49ers 30, Cardinals 10
Go ahead and spend this week believing McCoy is the solution, Cardinals’ fans. A Monday night session with Nick Bosa and friends should leave no doubt about Murray’s position with this team.
Jarrett Bell: 49ers 27, Cardinals 17
Nate Davis: 49ers 33, Cardinals 20
Tyler Dragon: 49ers 26, Cardinals 16
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