Tennessee Titans at Los Angeles Chargers: Predictions, picks and odds for NFL Week 15 matchup

Justin Herbert and the Los Angeles Chargers (7-6) are coming off their best win of the season and now play host to Derrick Henry's Tennessee Titans (7-6).
With momentum behind them, the Chargers get an entire week at home to prepare for the AFC South-leading Titans. Can Herbert, Austin Ekeler, Keenan Allen and the rest of the Los Angeles offense knock off another top playoff contender? The game is scheduled to kick off at 4:25 p.m. ET from SoFi Stadium.
Here's a look at the betting details and Paste BN's NFL staff picks for the Titans vs. Chargers Week 15 game:
Titans at Chargers odds, moneyline and over/under
- Spread: Chargers (-3)
- Moneyline: Chargers (-155); Titans (+130)
- Over/under: 46.5
- More odds, injury info for Titans vs. Chargers
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NFL Week 15 odds, predictions and picks
49ers vs. Seahawks | Colts vs. Vikings | Ravens vs. Browns | Dolphins vs. Bills | Lions vs. Jets | Chiefs vs. Texans | Steelers vs. Panthers | Eagles vs. Bears | Falcons vs. Saints | Cowboys vs. Jaguars | Cardinals vs. Broncos | Patriots vs. Raiders | Titans vs. Chargers | Bengals vs. Buccaneers | Giants vs. Commanders | Rams vs. Packers
Lorenzo Reyes: Chargers 28, Titans 21
Now that Los Angeles is finally approaching full health, their offense can click. That presumes that Joe Lombardi does what he did against the Dolphins and keeps Justin Herbert moving in the pocket. Tennessee has lost three in a row and has failed to cover any of those. Having Mike Williams healthy puts the Chargers over the edge.
Safid Deen: Chargers 23, Titans 17
Justin Herbert and the Chargers' offense found its groove against the Dolphins last week, and have a chance to continue rolling against the tough Titans. Tennessee dropped one to Jacksonville last week, where Ryan Tannehill was outclassed by Trevor Lawrence. I like Herbert over Tannehill in this one, too.
Richard Morin: Titans 28, Chargers 27
The Chargers put together their best performance of the season in their Week 14 triumph of the Dolphins, but I don't fully trust them just yet. Tennessee has lost three straight and picks up a tough road win in this one.
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