Tampa Bay Buccaneers at Arizona Cardinals: Predictions, picks and odds for NFL Week 16 matchup

The Tampa Bay Buccaneers (6-8) head west for a Christmas Day matchup against the Arizona Cardinals (4-10). This is a big game for the Buccaneers as they hold a half-game lead over the rest of the NFC South.
The Cardinals will likely start a third-string quarterback on Sunday. Backup signal-caller Colt McCoy is slated to miss the game. It will propel Trace McSorley into his first career NFL start against a respectable Buccaneers defense.
Tampa Bay needs to win this game. Can Tom Brady put together a strong finish to will the Buccaneers into the playoffs?
Here's a look at the betting details and Paste BN's NFL staff picks for the Buccaneers vs. Cardinals Week 16 game:
Buccaneers at Cardinals odds, moneyline and over/under
- Spread: Buccaneers (-7)
- Moneyline: Buccaneers (-360); Cardinals (+300)
- Over/under: 40.5
- More odds, injury info for Buccaneers at Cardinals
DIVISIONAL PUSH: Bucs aim to hold off Panthers, Falcons, Saints in NFC South
OPINION: Cardinals' head coaching job 'not that attractive' amid tumultuous NFL season
QB SHUFFLE: Cardinals to be cautious with McCoy, turn to Trayce McSorley, David Blough
NFL Week 16 odds, predictions and picks
Jaguars at Jets | Falcons at Ravens | Lions at Panthers | Bills at Bears | Saints at Browns | Seahawks at Chiefs | Giants at Vikings | Bengals at Patriots | Texans at Titans | Commanders at 49ers | Eagles at Cowboys | Raiders at Steelers | Packers at Dolphins | Broncos at Rams | Buccaneers at Cardinals | Chargers at Colts
Safid Deen: Buccaneers 24, Cardinals 14
Tom Brady and the Buccaneers are somehow, someway still in the playoff mix thanks to their friends in the NFC South. They’ll put together a performance like they did in the first half against Cincinnati, before faltering with four turnovers, and rebound with a win over the lowly Cardinals.
Victoria Hernandez: Buccaneers 21, Cardinals 9
Tom Brady is not letting a repeat of last week happen. He committed four turnovers. Not very seven-time Super Bowl champion of him. The Buccaneers need to wrap up the NFC South and shouldn't have a problem against a third-string quarterback not named Brock Purdy.
Jaylon Thompson: Buccaneers 20, Cardinals 10
The Buccaneers are holding onto a slim lead in the NFC South. A matchup against the lowly Cardinals is a holiday gift. Tampa Bay should find room on the ground and allow Tom Brady to dictate the pace. The Cardinals are down to their third-string quarterback as injuries have ravaged this team.
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- All players
- Quarterback
- Running back
- Wide receiver
- Tight end
- Tackle
- Guard
- Center
- Kickers
- Edge rusher
- Safety
- Cornerback
- Linebacker
- Interior defensive linemen
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