Dallas Cowboys at San Francisco 49ers: Predictions, picks and odds for NFL playoff matchup

Dak Prescott had the game of his career in a romp against Tom Brady and Co., and now leads the Dallas Cowboys to a divisional-round clash with Brock Purdy and the San Francisco 49ers.
Can the Cowboys, who hadn't won a playoff game since the 20th century, keep their season going against a 49ers team who made easy work of the Seattle Seahawks last week? Can Purdy, the final pick in the 2022 draft, keep his unlikely ascent on schedule? The game kicks off Sunday at 6:30 p.m. ET from Levi's Stadium.
Here's a look at the betting details and Paste BN's NFL staff picks for the Cowboys vs. 49ers NFC divisional playoff game:
Cowboys at 49ers odds, moneyline and over/under
- Spread: 49ers (-4)
- Moneyline: 49ers (-200); Cowboys (+170)
- Over/under: 46.5
- More odds, injury info for 49ers vs. Cowboys
GOOD OR BAD JOB? Ranking NFL's five* open head coaching jobs from best to worst after Cardinals fire Kliff Kingsbury
HOW TO WATCH: When do the NFL playoffs start? Matchups, game times, TV info leading up to Super Bowl 57
STAFF PICKS: Paste BN Sports' NFL divisional playoff, Super Bowl picks: Who reaches conference championships?
NFL playoff bracket odds, predictions and picks
Jaguars vs. Chiefs | Giants vs. Eagles | Bengals vs. Bills | Cowboys vs. 49ers
Lorenzo Reyes: 49ers 31, Cowboys 23
The Niners look like one of the most well-rounded, balanced teams in the playoff field. Kyle Shanahan devised a scheme that has allowed Purdy to shine. And while the Cowboys shook out of a recent slump in the wild-card round, the 49ers' defense is elite at every level and should give the Cowboys fits.
Safid Deen: 49ers 31, Cowboys 23
Despite Dak Prescott and the Cowboys' offense finding its rhythm in Tampa Bay last week, it’ll be a different story going up against Nick Bosa and the 49ers’ stout defense. Dallas couldn’t beat San Francisco with a home-field advantage in the playoffs last year, so I certainly don’t expect them to beat the 49ers, with running back Christian McCaffrey. I’m taking the Niners at home, while the Cowboys’ season ends on Sunday night.
Richard Morin: 49ers 28, Cowboys 20
The Cowboys got the monkey off their back with a win wild-card weekend, but the 49ers are a much more solid unit than the Tampa Bay Buccaneers. How far can Purdy ride this thing?
Jarrett Bell: Cowboys 28, 49ers 27
Nate Davis: 49ers 27, Cowboys 24
Tyler Dragon: 49ers 28, Cowboys 20
32 THINGS WE LEARNED: Takeaways from NFL's 'Super Wild Card Weekend': 49ers roll, close games highlight slate
NEW BUCKETS: The NFL has returned alternate helmets in 2022: Ranking all 13 from best to worst
IN-DEPTH: The NFL coaches project
NFL salaries: These are the highest-paid NFL players
- All players
- Quarterback
- Running back
- Wide receiver
- Tight end
- Tackle
- Guard
- Center
- Kickers
- Edge rusher
- Safety
- Cornerback
- Linebacker
- Interior defensive linemen
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See applicable operator site for its terms and conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER. Must be 21 or older to gamble.