Los Angeles Chargers at Tennessee Titans: Predictions, picks and odds for NFL Week 2 game

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The Los Angeles Chargers (0-1) were minutes away from a Week 1 win and will brush off their shoulders to try again in a matchup against the Tennessee Titans (0-1) in Nashville at Nissan Stadium.

Justin Herbert scored two touchdowns in the Chargers' loss — one through the air and one on the ground. Los Angeles scored three total rushing touchdowns, including one from Austin Ekeler who had 117 yards on the day.

Ryan Tannehill threw three interceptions and Derrick Henry was held to 63 yards in their defeat against the Saints.

Last season, the Chargers pulled out a narrow 17-14 victory over the Titans with a game-winning field goal. Both quarterbacks combined for three interceptions.

Will Herbert continue to show off his star power? Or will Henry steal the show?

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Titans vs. Chargers odds, moneyline, over/under

The Los Angeles Chargers are favorites to defeat the Tennessee Titans, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

Spread: Chargers (-2.5)
Moneyline: Chargers (-145); Titans (+120)
Over/under: 45.5

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NFL Week 2 odds, predictions and picks

Lorenzo Reyes: Chargers 31, Titans 23

In the first game of the Kellen Moore era for L.A., the Chargers' offense popped off, but they faced the problem of running into an explosive Dolphins squad. The Chargers will have a far easier time defending the Titans, especially in light of Ryan Tannehill’s struggles and Tennessee’s inability to punch it in the end zone.

Tyler Dragon: Chargers 28, Titans 24

The Chargers pass defense was abysmal versus Miami. Tyreek Hill might be still running around in Los Angeles. Lucky for the Chargers, the Titans don’t have an explosive passing game. The Bolts bounce back in Week 2 with a solid defensive performance and a balanced offensive attack. The Titans fall to 0-2.

Victoria Hernandez: Chargers 24, Titans 10

While both teams have revered running backs, the difference in this matchup is the quarterbacks. Justin Herbert is a rising star who had the time run out on him last week and has a much more healthy roster than last year's matchup. Ryan Tannehill is an aging veteran who can't seem to find his rhythm.

Jordan Mendoza: Chargers 29, Titans 17:

The Los Angeles defense was non-existent in a wild loss to Miami, but they won’t be facing as explosive of an offense against Tennessee. The defense should recover from an abysmal start while the offense has another week of putting up big points.

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