San Francisco 49ers at Los Angeles Rams: Predictions, picks and odds for NFL Week 2 game

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The Los Angeles Rams (1-0) host NFC West rival the San Francisco 49ers (1-0) in a heated matchup.

Matthew Stafford and Co. have their home opener at SoFi Stadium after putting a beatdown on the Seattle Seahawks in Week 1. The Rams held the Seahawks offense to 180 yards in the win.

Among the other teams that had large victories in their season openers were the 49ers, who put a thrashing on the Pittsburgh Steelers in the Steel City. Brandon Aiyuk had a 129-yard day and was responsible for both of Brock Purdy's touchdowns in the victory. Not to mention Drake Jackson had three sacks.

Which team will carry its momentum from a big Week 1 win?

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Rams vs. 49ers odds, moneyline, over/under

The San Francisco 49ers are favorites to defeat the Los Angeles Rams, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

Spread: 49ers (-7.5)
Moneyline: 49ers (-350); Rams (+260)
Over/under: 45.5

Not interested in this game? Our guide to the NFL betting odds, picks and spreads has you covered with Thursday Night Football odds, Sunday Night Football odds and/or Monday Night Football odds.

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NFL Week 2 odds, predictions and picks

Lorenzo Reyes: 49ers 30, Rams 19

Honestly, the 49ers, after their complete domination of the Steelers, might be the best team in football. They’re explosive on offense, Brock Purdy is healthy and — with Nick Bosa back in the fold — have a dominant front seven. The Rams pulled off a nice upset in Week 1, but their lack of depth makes this an awful matchup.

Tyler Dragon: 49ers 31, Rams 16

The 49ers played like the best team in the NFL in Week 1. The Cooper Kupp-less Rams got a big win in Seattle last week, but the 49ers have owned the Rams in the regular season. The Rams haven’t defeated the 49ers in the regular season since 2018.

Victoria Hernandez: 49ers 28, Rams 17

The 49ers' explosive offense will be slowed down a bit by Aaron Donald and crew after Brandon Aiyuk balled out last week. But San Francisco's defense is even more stalwart and will ensure the victory.

Jordan Mendoza: 49ers 27, Rams 17

The Rams' offense was surprisingly efficient against Seattle, but it will face a much stronger defense against San Francisco. The offense will be able to generate points, but the 49ers offense thrives once again in front of a 49er-heavy SoFi Stadium.

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