Los Angeles Rams at Indianapolis Colts: Predictions, picks and odds for NFL Week 4 game

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There's still a lot unknown about the Los Angeles Rams (1-2) and the Indianapolis Colts (2-1), but the two sides will face off inside Lucas Oil Stadium Sunday.

Los Angeles had a chance to capitalize on an injured Joe Burrow and the Cincinnati Bengals on "Monday Night Football," but the offense couldn't overcome a tenacious pass rush and didn't get a touchdown until the final minutes as they dropped a Super Bowl 56 rematch.

The Colts weren't figured to be much of a winning team to start the year, but one look at them and they have notched back-to-back wins. Even without Anthony Richardson, Indianapolis was able to grind out an overtime win against Baltimore and take an early lead in the AFC South.

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Colts vs. Rams odds, moneyline, over/under

The Colts are favorites to defeat the Rams, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

Spread: Colts (-1)
Moneyline: Colts (-120); Rams (+100)
Over/under: 46.5

Not interested in this game? Our guide to the NFL betting odds, picks and spreads has you covered with Thursday Night Football odds, Sunday Night Football odds and/or Monday Night Football odds.

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NFL Week 4 odds, predictions and picks

Lorenzo Reyes: Colts 24, Rams 20

Shane Steichen has gotten this group to play tough and Indy will be better on offense if Anthony Richardson is able to return. The Rams have been a solid play against the spread this season but they still have too much inconsistency on offense and their defense has forced just one turnover all season long.

Tyler Dragon: Colts 20, Rams 17

The Rams have lost two one-score games, but the absence of Cooper Kupp is becoming more apparent each week. The Colts are better than expected and could get promising rookie Anthony Richardson back in Week 4.

Victoria Hernandez: Colts 23, Rams 20

The Rams have a slightly shorter week after losing on Monday night and they will be tired playing in back-to-back road games. The Colts, meanwhile, have momentum coming home after two road wins and know they can hold down the fort until Anthony Richardson is one hundred percent.

Jordan Mendoza: Colts 24, Rams 20

The Colts have proven that even without their quarterback of the future, they can't be counted out after a major win on the road in Baltimore. Whether Anthony Richardson plays or not, Indianapolis gets another statement win by making life difficult for Matthew Stafford for their first win over the Rams since they were in St. Louis (2009).

You can view the full list of Paste BN's NFL expert predictions here.

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