San Francisco 49ers at Arizona Cardinals: Predictions, picks and odds for NFL Week 15 game

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There's a new No. 1 seed in the NFC playoff standings.

The San Francisco 49ers (10-3) are the new leaders in the NFC, and they'll attempt to strength their hold on the top spot when they visit the Arizona Cardinals (3-10) in Week 15.

San Francisco's dominance continued last week with another double-digit victory over the Seattle Seahawks, as it was also the fifth-straight game in which the 49ers won by at least two scores. The offense is clicking all over the field, and the defense remains one of the best in the NFL with a league-best 15.8 points per game.

Arizona had the past week off, but things are looking promising with Kyler Murray back as the Cardinals are 2-2 since their quarterback returned. With only four games left, Murray still has time to prove he is still the guy for the team and there is no need to draft another quarterback next season.

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Cardinals vs. 49ers odds, moneyline, over/under

The 49ers are favorites to defeat the Cardinals, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023, including the new ESPN BET app.

Spread: 49ers (-12.5)
Moneyline: 49ers (-900); Cardinals (+600)
Over/under: 48

Not interested in this game? Our guide to NFL betting odds, picks and spreads has you covered with Thursday Night Football odds, Sunday Night Football odds and/or Monday Night Football odds.

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NFL Week 15 odds, predictions and picks

Lorenzo Reyes: 49ers 37, Cardinals 13

The Niners are absolutely rolling through other teams. San Francisco looks like the most balanced and complete roster in the NFL. Even with the big line, backing them here is the safe play.

Tyler Dragon: 49ers 30, Cardinals 14

Is there a hotter team in the NFL right now? The 49ers have won five consecutive games. San Francisco is the first team in the NFL to clinch a playoff spot. The 49ers have held each of their opponents under 20 points during their five-game winning streak. The 49ers have the NFL’s second-ranked offense, and its defense allows the fewest points per game. As for the Cardinals? They have four games remaining in their season.

Safid Deen: 49ers 27, Cardinals 13

Kyler Murray might give the 49ers some trouble defensively, but San Francisco will roll over the lowly Cardinals and maintain their top seed in the NFC.

Victoria Hernandez: 49ers 30, Cardinals 13

The 49ers have their playoff spot secured and are playing on all cylinders. The Cardinals don’t pose a threat on any level even with Kyler Murray back.

Jordan Mendoza: 49ers 31, Cardinals 13

It wasn't much of a contest the first time these two squads played earlier this season, but Kyler Murray should add some intrigue to this matchup. Still, the 49ers defense hasn't allowed more than 20 points since they came back from their bye week. Another dominant performance results in a comfortable win for San Francisco.

You can view the full list of Paste BN's NFL expert predictions here.

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