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Titans at Colts: Predictions, picks, odds for NFL Week 16 game


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The Indianapolis Colts aren't dead, but they are certainly on life support. At 6-8, one more loss would almost surely eliminate the Colts from playoff contention. Of course, even if they win this weekend, their odds of reaching the postseason are not very good. That said, you can bet they'll fight until their last breath.

Standing in their way this Sunday is a familiar opponent who has already been eliminated, the Tennessee Titans. Although the Titans have been eliminated, they cannot be underestimated. Divisional games tend to be much closer than they should be, and the Colts cannot afford to look past their Nashville nemeses.

Here are our experts' predictions for this AFC South showdown.

Colts vs. Titans odds, moneyline, over/under

The Colts are favorites to defeat the Titans, according to the BetMGM NFL odds. Not interested in this game? Check out expert picks and best bets for every NFL game this week.

  • Spread: Colts (-3.5)
  • Moneyline: Colts (-190); Titans (+155)
  • Over/under: 42.5    

NFL Week 16 odds, predictions and picks

Chargers vs. Broncos | Chiefs vs. Texans | Ravens vs. Steelers | Bengals vs. Browns | Falcons vs. Giants | Bills vs. Patriots | Panthers vs. Cardinals | Bears vs. Lions | Colts vs. Titans | Jets vs. Rams | Commanders vs. Eagles | Seahawks vs. Vikings | Raiders vs. Jaguars | Dolphins vs. 49ers | Cowboys vs. Buccaneers | Packers vs. Saints

Tyler Dragon: Colts 24, Titans 17

The Colts’ playoff hopes took a hit last week in Denver. Indy closes out the season against three team well under .500.

Jordan Mendoza: Colts 20, Titans 15

Can a quarterback change light a spark for Tennessee? While more promising, Indianapolis has too much talent. 

(This story was updated to change a video.)