Bills at Patriots: Predictions, picks, odds for NFL Week 18 game
The Buffalo Bills (13-3) have already secured their seed in the playoffs. Could the New England Patriots (3-13) be the one to secure the No. 1 pick?
Just to make sure it clinched the No. 2 spot in the AFC, Buffalo put the hammer down on the New York Jets last week. Now the Bills have a chance to rest some players ahead of the playoff run, something not many teams will get to do in Week 18.
It's simple for New England: Lose and the Patriots will be on the clock. New England fans would love to make the first selection in the 2025 draft, but there is a chance the team can hang with the B-squad Buffalo will likely throw out.
Patriots vs. Bills odds, moneyline, over/under
The Bills are favorites to defeat the Patriots, according to the BetMGM NFL odds. Not interested in this game? Check out expert picks and best bets for every NFL game this week.
- Spread: Bills (-2.5)
- Moneyline: Bills (-140); Patriots (+115)
- Over/under: 38
NFL Week 18 odds, predictions and picks
Cardinals vs. 49ers | Falcons vs. Panthers | Ravens vs. Browns | Cowboys vs. Commanders | Broncos vs. Chiefs | Lions vs. Vikings | Packers vs. Bears | Colts vs. Jaguars | Rams vs. Seahawks | Raiders vs. Chargers | Patriots vs. Bills | Jets vs. Dolphins | Eagles vs. Giants | Steelers vs. Bengals | Buccaneers vs. Saints | Titans vs. Texans
Lorenzo Reyes: Bills 26, Patriots 8
Buffalo will almost certainly rest Josh Allen (after he plays early on to preserve a consecutive starts streak). Even then, I trust their bench players more than I trust New England’s starters.
Richard Morin: Patriots 18, Bills 16
The Patriots have a chance to wreck their future if they defeat Buffalo's bench suad. Of course, that's what they'll do.
Jordan Mendoza: Bills 16, Patriots 13
How will New England look when it faces mostly backups? The Patriots have a chance to win this one, but they shouldn't try to.