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San Francisco 49ers NFL draft picks 2025: Full list of team's round-by-round selections

Ayrton Ostly   Paste BN
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The San Francisco 49ers made the Super Bowl for the second time in five years in 2023. For the second time, they fell short against the Kansas City Chiefs.

They followed that campaign with one of the tougher seasons of coach Kyle Shanahan's tenure. Injuries kept stars Brandon Aiyuk and Christian McCaffrey from contributing much at all during the season. Off-field concerns, including first-round pick Ricky Pearsall being shot in the chest before the season and cornerback Charvarius Ward's family tragedy, added to the malaise.

That led to a 6-11 campaign, the 49ers' worst since 2020 when San Francisco had an injury-riddled season after a run to the Super Bowl.

That led to lots of changes already this offseason. Franchise fixtures Deebo Samuel Sr. and Dre Greenlaw are out of the building, as are former starters Aaron Banks, Talanoa Hufanga and Ward. After a down year for the defense, San Francisco brought back former defensive coordinator Robert Saleh for that role in 2025.

Changes don't have to stop there, though. San Francisco is armed with lots of picks in the 2025 NFL draft, including four in the top 100 selections, and could make more long-term investments for the future.

Here's everything to know about the 49ers' draft outlook ahead of the 2025 NFL Draft:

49ers 2025 NFL Draft picks

The 49ers have 11 picks in the 2025 NFL draft, tied for the most in the NFL. Here's the complete list:

  • Round 1, Pick 11: Mykel Williams, edge, Georgia

He could be a phenomenal value at this spot and a very nice backfill for a badly depleted Niners D-line, formerly the foundation of their defense. Williams’ numbers for the Bulldogs (14 sacks and 57 hurries in three seasons) are actually unusually good given the depth of that defense and how rarely it had to be on the field. He's also tough, playing through a high-ankle sprain most of last season. Williams could make quite a tandem with 2022 Defensive Player of the Year Nick Bosa. – Nate Davis, Paste BN Sports

  • Round 2, Pick 43: Alfred Collins, DT, Texas

The Niners continue to rebuild their depleted D-line, addressing the interior with this massive pick. With 35 hurries since 2023, Collins (6-6, 332) can draw attention from DE Nick Bosa or capitalize on the blocking focus Bosa demands. – Nate Davis, Paste BN Sports

  • Round 3, Pick 75: Nick Martin, LB, Oklahoma State

He led the Big 12 with 83 tackles in 2023 before a knee injury ruined his 2024 campaign. But with Dre Greenlaw gone to Denver, Niners star LB Fred Warner needs a new Robin in Silicon Valley. – Nate Davis, Paste BN Sports

  • Round 3, Pick 100: Upton Stout, CB, Western Kentucky

He’s small (5-9, 181) but quick enough to make a living in nickel and dime packages at the pro level. – Nate Davis, Paste BN Sports

  • Round 4, Pick 113: CJ West, DT, Indiana
  • Round 4, Pick 138: Jordan Watkins, WR, Ole Miss
  • Round 5, Pick 147 (from Saints via Commanders): Jordan James, RB, Oregon
  • Round 5, Pick 160 (from Vikings): Marques Sigle, S, Kansas State
  • Round 7, Pick 227: Kurtis Rourke, QB, Indiana
  • Round 7, Pick 249: Connor Colby, G, Iowa
  • Round 7, Pick 252: Junior Bergen, WR, Montana

49ers 2025 NFL draft needs

Defensive line

What was once the calling card of the 49ers' defense has become a weak point on the roster. Edge rusher Nick Bosa is a star but there's little help around him. Luckily, this is a deep draft on the defensive line, both at interior and on the edge. San Francisco should be able to find multiple players with upside to develop in the trenches.

Offensive tackle

Trent Williams will be 37 this season and Colton McKivitz is a free agent in 2026. Swing tackle Jaylon Moore took a big deal to sign with the Chiefs. San Francisco needs to find a long-term solution for at least one of those spots sooner than later. It's not a great tackle class but there could be value picks worth sitting and developing for a year in the middle rounds.

Cornerback

The team lost Ward, the former second-team All-Pro cornerback, in free agency. They signed multiple cornerbacks in free agency but none are preventing investment at that spot in the secondary. Deommodore Lenoir got an extension and Renardo Green played well as a rookie in 2024, making it less pressing, but if the 49ers want to contend in the postseason again they'll need more help on the back end.

49ers 2025 NFL mock draft

Here's what the 49ers could do in this year's draft:

  • Round 1, Pick 11: Edge Mykel Williams, Georgia
    • San Francisco misses out on the top tackle prospects and settles for a long, powerful edge rusher in the mold they've historically liked. Williams played hurt in 2024 and showed flashes of potential. With the 49ers' infrastructure, he could reach that in time.
  • Round 2, Pick 43: DT Darius Alexander, Toledo
    • The Toledo product made the most of the Senior Bowl and combine to show off his impressive mix of length, athleticism and burst. The 49ers' defense suffered without a force on the interior last season and Alexander should be a building block for the future.
  • Round 3, Pick 75: TE Harold Fannin Jr., Bowling Green
  • Round 3, Pick 100: OT Ozzy Trapillo, Boston College
  • Round 4, Pick 113: CB Zah Frazier, UT-San Antonio
  • Round 4, Pick 138: CB Zy Alexander, LSU
  • Round 5, Pick 147: DT C.J. West, Indiana
  • Round 5, Pick 160: IOL Caleb Rogers, Texas Tech
  • Round 7, Pick 227: RB Montrell Johnson Jr., Florida
  • Round 7, Pick 249: LB Shemar James, Florida
  • Round 7, Pick 252: K Andres Borregales, Miami

2025 NFL Draft: Every team's picks

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