Arizona Cardinals odds 2025: Team favored to win 5 of 1st 6 games
The Arizona Cardinals open the 2025 NFL regular season on Sept. 7 against the New Orleans Saints at Caesars Superdome in New Orleans.
Who is favored in that game and other Cardinals games this season?
DraftKings Sportsbook has odds listed for every Cardinals regular-season game in 2025, providing us a look at early betting odds for the team's games.
Here's the early point spread, moneyline and over/under (point total) for every Cardinals game on the 2025 NFL schedule.
Arizona is currently favored in five of its first six games on the season, giving Kyler Murray and company a chance for a hot start in this pivotal season for the Cardinals franchise.
A hot start might be crucial for Arizona as the team is favored in only two of its final 11 games and is a betting favorite in only seven of its 17 regular-season games this season.
NFL Week 1 odds: Arizona Cardinals at New Orleans Saints (Sept. 7)
- Point spread: Cardinals -5.5; Saints +5.5
- Moneyline: Cardinals -245; Saints +200
- Point total: 42.5
NFL Week 2 odds: Carolina Panthers at Arizona Cardinals (Sept. 14)
- Point spread: Cardinals -4.5; Panthers +4.5
- Moneyline: Cardinals -205; Panthers +170
- Point total: 46.5
NFL Week 3 odds: Arizona Cardinals at San Francisco 49ers (Sept. 21)
- Point spread: 49ers -3.5; Cardinals +3.5
- Moneyline: 49ers -185; Cardinals +154
- Point total: 47.5
NFL Week 4 odds: Seattle Seahawks at Arizona Cardinals (Sept. 25)
- Point spread: Cardinals -2.5; Seahawks +2.5
- Moneyline: Cardinals -135; Seahawks +114
- Point total: 46.5
NFL Week 5 odds: Tennessee Titans at Arizona Cardinals (Oct. 5)
- Point spread: Cardinals -5.5; Titans +5.5
- Moneyline: Cardinals -238; Titans +195
- Point total: 46.5
NFL Week 6 odds: Arizona Cardinals at Indianapolis Colts (Oct. 12)
- Point spread: Cardinals -1.5; Colts: +1.5
- Moneyline: Cardinals -120; Colts +100
- Point total: 47.5
NFL Week 7 odds: Green Bay Packers at Arizona Cardinals (Oct. 19)
- Point spread: Packers -1.5; Cardinals +1.5
- Moneyline: Packers -122; Cardinals +102
- Point total: 47.5
NFL Week 9 odds: Arizona Cardinals at Dallas Cowboys (Nov. 3)
- Point spread: Cowboys -1.5; Cardinals +1.5
- Moneyline: Cowboys -120; Cardinals +100
- Point total: 47.5
NFL Week 10 odds: Arizona Cardinals at Seattle Seahawks (Nov. 9)
- Point spread: Seahawks -1.5; Cardinals +1.5
- Moneyline: Seahawks -122; Cardinals +102
- Point total: 45.5
NFL Week 11 odds: San Francisco 49ers at Arizona Cardinals (Nov. 16)
- Point spread: 49ers -1.5; Cardinals +1.5
- Moneyline: 49ers -122; Cardinals +102
- Point total: 47.5
NFL Week 12 odds: Jacksonville Jaguars at Arizona Cardinals (Nov. 23)
- Point spread: Cardinals -3; Jaguars +3
- Moneyline: Cardinals -155; Jaguars +130
- Point total: 47.5
NFL Week 13 odds: Arizona Cardinals at Tampa Bay Buccaneers (Nov. 30)
- Point spread: Buccaneers -3.5; Cardinals +3.5
- Moneyline: Buccaneers -175; Cardinals +145
- Point total: 48.5
NFL Week 14 odds: Los Angeles Rams at Arizona Cardinals (Dec. 7)
- Point spread: Rams -1.5; Cardinals +1.5
- Moneyline: Rams -118; Cardinals -102
- Point total: 47.5
NFL Week 15 odds: Arizona Cardinals at Houston Texans (Dec. 14)
- Point spread: Texans -2.5; Cardinals +2.5
- Moneyline: Texans -130; Cardinals +110
- Point total: 45.5
NFL Week 16 odds: Atlanta Falcons at Arizona Cardinals (Dec. 21)
- Point spread: Cardinals -3.5; Falcons +3.5
- Moneyline: Cardinals -175; Falcons +145
- Point total: 46.5
NFL Week 17 odds: Arizona Cardinals at Cincinnati Bengals (TBD)
- Point spread: Bengals -3.5; Cardinals +3.5
- Moneyline: Bengals -185; Cardinals +154
- Point total: 47.5
NFL Week 18 odds: Arizona Cardinals at Los Angeles Rams (TBD)
- Point spread: Rams -4.5, Cardinals +4.5
- Moneyline: Rams -205; Cardinals +170
- Point total: 45.5
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