Los Angeles Angels at San Francisco Giants odds, picks and best bets

The Los Angeles Angels (8-16) and San Francisco Giants (9-16) move north for the start of the back end of this four-game, home-and-home series Wednesday. First pitch is set for 9:45 p.m. ET at Oracle Park. We analyze the Angels-Giants MLB betting odds and lines, with picks and best bets.

Tuesday: The Giants prevailed 8-2 to even the series and snap a five-game skid. The Angels took Monday's opener 7-6 on 2B Tommy La Stella's walk-off, two-run homer in the ninth inning.

Angels at Giants: Projected starting pitchers

LHP Patrick Sandoval vs. RHP Johnny Cueto

Sandoval, who made his MLB debut last season, is still searching for his first career win. He is winless in 12 starts.

• This season: 0-2, 3.94 ERA (7 ER, 16 IP) in 3 starts
• Last start: Loss, 6 IP, 4 ER, 6 H, 2 BB, 5 K vs. Los Angeles Dodgers Friday - Angels lost 7-4
• Career vs. Giants: 0 appearances

Cueto is coming off his longest outing of 2020, working 7 innings and tossing 104 pitches, but unfortunately, the bullpen failed him. He took a no-hitter into the sixth inning vs. the Dodgers two starts ago.

• This season: 1-0, 4.62 ERA (13 ER, 25 1/3 IP) in 5 starts
• Last start: No decision, 7 IP, 2 ER, 3 H, 2 BB, 5 K vs. Oakland A's Friday - Giants lost 8-7 in 10 innings
• Career vs. Angels: 2-0, 0.86 ERA (2 ER, 21 IP) in 3 starts, tossing 6 scoreless innings when he last faced them in 2018

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Angels at Giants: Key injuries

(Get the latest injury news here.)

Angels

• RP Cam Bedrosian (groin) out
• C Jason Castro (neck) out
• SS Andrelton Simmons (ankle) out

Giants

• OF Austin Slater (elbow) questionable

Also see: BaseballHQ Fantasy Baseball

Angels at Giants: Odds, lines, picks and betting tips

MLB odds courtesy of BetMGM; access Paste BN Sports for a full list. Odds last updated at 6:05 p.m. ET.

Prediction

Giants 7, Angels 4

Moneyline (ML)

The GIANTS (+ 130) are the STRONGEST PLAY with Cueto on the hill. Surprisingly, with CF Mike Trout, 3B Anthony Rendon and future Hall of Fame 1B Albert Pujols, the Angels (-143) rank 22nd in the majors - 11th in the AL - with a .228 team batting average. The stars are aligned for Cueto to have a good outing.

New to sports betting? Every winning $1 bet on the Giants ML will profit $1.30. A $1 winning bet on the Angels profits only $0.69.

Run line/Against the spread (ATS)

As long as the juice doesn't climb above -135, I'm willing to make a small wager on the GIANTS ( +1.5, -129). They're 4-1 in their last five vs. the RL. The Angels (-1.5, +106) are 1-5 in their last six vs. the RL, and 9-15 vs. the RL overall. Otherwise, I'll pass.

Over/Under (O/U)

The OVER 9 (- 110) is the play. The Giants (14-7-4 O/U record) and the Angels (16-8 O/U) are the best Over teams in the majors - hitting the OVER 66.7 percent of the time.

The Angels have actually played 6 Overs in a row and are 8-1 O/U in their last nine, while the Giants have played 5 Overs in a row and are 8-1-1 O/U in their last 10. Here's counting on the Overs to continue Wednesday night.

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