Real Madrid vs. PSG odds, picks and predictions

PSG heads to the Santiago Bernabéu on Wednesday for the second leg of a UEFA Champions League Round of 16 matchup with Real Madrid. Kickoff is scheduled for 3 p.m. ET. Below, we preview the Real Madrid vs. PSG odds and lines, and make our best Champions League bets, picks and predictions.

PSG was among the favorites to win the Champions League at the start of the competition, but it faced a challenge getting through Real Madrid's defense in winning 1-0 at home in the first leg of the two-leg Round of 16 matchup.

Led by a trio of attacking forwards (F Lionel Messi, F Kylian Mbappe, and F Neymar), PSG currently sits atop Ligue 1, first in the standings by 13 points.

It finished second in Group A with 3 wins, 2 draws and a loss, a group featuring Manchester City. PSG totaled 21 shots and 8 on target in the first meeting of these two sides.

As for Real Madrid, it managed just 3 shots and none on target. It does currently sit atop La Liga and easily won Group D. In 27 La Liga matchups, Real has allowed just 21 goals. Its strength is in its backline.

Real Madrid vs. PSG: Odds, picks and predictions

Odds provided by Tipico Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:03 a.m. ET.

• Money line: Real Madrid +150 (bet $100 to win $150) | PSG +165 (bet $100 to win $165) | Draw +260
• Over/Under: 2.5 (O: -175 | U: +135)