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First look: USC at Oregon odds and lines


The USC Trojans (7-3, 5-2 Pac-12) and Oregon Ducks (8-1, 5-1) meet Saturday night in Eugene. Kickoff at Autzen Stadium is slated for 10:30 p.m. ET (FOX). Below, we look at USC vs. Oregon odds from FanDuel Sportsbook. Also see: SportsbookWire's college football picks and predictions.

Southern Cal continued its defensive struggles in a 55-42 loss (as a +2.5 underdog) Saturday to current-No. 5 Washington (US LBM Coaches Poll powered by Paste BN Sports), The Trojans allowed over 500 yards for a 2nd-straight game and a 4th time this season.

No. 6 Oregon ripped Cal Saturday, easily covering as a -26.5 favorite in a 63-19 triumph. QB Bo Nix threw 4 TD passes and ran for 2 more, as the Ducks upped their FBS-leading scoring average to 47.4 points per game.

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USC at Oregon odds

FanDuel Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 6:49 p.m. ET.

  • Moneyline: USC +580 (bet $100 to win $580) | Oregon -880 (bet $880 to win $100)
  • Against the spread (ATS): USC +14.5 (-110) | Oregon -14.5 (-110)
  • Over/Under (O/U): 74.5 (O: -110 | U: -110)

2023 betting stats

  • ML: USC 7-3 | Oregon 8-1
  • ATS: USC 2-8 | Oregon 8-1
  • O/U: USC 9-1 | Oregon 4-5

USC vs. Oregon head-to-head

Southern Cal and Oregon have not met since 2020. The Ducks won that contest -- the 2020 Pac-12 title game -- 31-24 and have won 4 of 5 from the Trojans since 2012.

USC leads 38-22-2 in the all-time series that dates back to 1915.

The Ducks are 4-1 ATS over the last 5 meetings in the series. At Autzen Stadium, Oregon is 4-5 ATS since 1998. The Over has cashed in 3 straight games in Eugene.

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