First look: San Francisco 49ers at Jacksonville Jaguars odds and lines

Payton Shanks | Staff Writer

The San Francisco 49ers (5-3) travel to take on the Jacksonville Jaguars (6-2) Sunday. Kickoff from EverBank Stadium is set for 1 p.m. ET (FOX). Below, we look at 49ers vs. Jaguars odds from BetMGM Sportsbook. Also see: SportsbookWire's NFL picks and predictions.

San Francisco is on a 3-game losing skid and is coming off a seemingly much-needed bye week. This normally high-powered 49es offense has scored only 17 points in each of its last 3 losses. All 5 of QB Brock Purdy's interceptions on the season have come during this losing streak.

Jacksonville, who was also off last week, looks to continue its 5-game winning streak. The Jaguars have won by an average margin of 11 points during the streak and have scored over 20 points in each of the 5 wins.

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49ers at Jaguars odds

Provided by BetMGM Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 1:01 a.m. ET.

Moneyline (ML): 49ers -155 (bet $155 to win $100) | Jaguars +130 (bet $100 to win $130)
Against the spread (ATS): 49ers -3 (-105) | Jaguars +3 (-115)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

2023 betting stats

ML: 49ers 5-3 | Jaguars 6-2
ATS: 49ers 4-4 | Jaguars 6-2
O/U: 49ers 5-3 | Jaguars 4-4

49ers vs. Jaguars head-to-head

These squads have only met 6 times, with the 49ers leading 4-2. San Francisco has won the last 4 matchups, outscoring the Jaguars 136-56 during that span. The 49ers have scored 30 or more points in their last 3 meetings, including a 30-10 win in Jacksonville in 2021.

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