Cleveland Cavaliers at Portland Trail Blazers odds, picks and predictions

Kevin Erickson | Staff Writer

The Cleveland Cavaliers (4-6) wrap up a 4-game Western Conference road trip on Wednesday against the Portland Trail Blazers (3-7) at Moda Center. Tip-off is scheduled for 10 p.m. ET. Let's analyze BetMGM Sportsbook's lines around the Cavaliers vs. Trail Blazers odds and make our expert NBA picks and predictions.

Season series: First meeting; Cavaliers won 2-0 in 2022-23

The Cavaliers were on the short end of a 132-120 score in Sacramento against the Kings on Monday as a 1-point underdog as the Over (229.5) connected. The Cavs have alternated non-covers and covers in each of the past 7 games. The Over has hit in all 3 games on the road trip, while going 4-0 in the past 4 games overall on the road.

The Trail Blazers return home after an 0-3 straight up road trip, although Portland was a respectable 2-1 against the spread (ATS). It is also 5-2 ATS in 7 games overall since Oct. 30. The Blazers have won and covered the past 2 games against Eastern Conference teams, too.

Cavaliers at Trail Blazers odds

Provided by BetMGM Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:05 a.m. ET.

Moneyline (ML): Cavaliers -450 (bet $450 to win $100) | Trail Blazers +340 (bet $100 to win $340)
Against the spread (ATS): Cavaliers -9.5 (-110) | Trail Blazers +9.5 (-110)
Over/Under (O/U): 221.5 (O: -110 | U: -110)

Cavaliers at Trail Blazers key injuries

Cavaliers

G Darius Garland (neck) out
F Isaac Okoro (knee) out

Trail Blazers

G Malcolm Brogdon (hamstring) questionable
G Scott Henderson (ankle) out

For most recent updates: Official NBA injury report.

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Cavaliers at Trail Blazers picks and predictions

Prediction

Cavaliers 115, Trail Blazers 110

Moneyline

The Cavaliers (-450) will cost you 4 1/2 times your potential return, and that's way too much risk for not enough reward. The Cavs are just 1 game better than the Trail Blazers (+340) in the standings, and, if anything, with Garland sidelined for the visitors, the Blazers might be worth playing lightly.

PASS.

Against the spread

The TRAIL BLAZERS +9.5 (-110) are a strong play catching nearly double digits at home.

Yes, the Cavaliers -9.5 (-110) have won and covered 4 straight meetings, but they're banged up and at the end of a long and winding road trip. The Blazers should be able to at least keep this game within single digits.

Over/Under

OVER 221.5 (-110) is the lean, but go very, very lightly.

The Under has cashed in 3 of the past 4 meetings in this series, but recently, the Over has cashed for both teams this season.

The Over is 3-2 in the past 5 games for the Blazers, allowing 112 or more points in each of the past 5 outings.

For the Cavs, the Over has hit in all 3 games on the current road trip, while going 5-1 in 6 games away from home this season. While there is concern with Garland and Okoro on the shelf, still go high.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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