Tampa Bay Buccaneers at San Francisco 49ers odds, picks and predictions

Ryan Dodson | Staff Writer

The Tampa Bay Buccaneers (4-5) and San Francisco 49ers (6-3) tangle Sunday at Levi's Stadium. Kickoff is scheduled for 4:05 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook's lines around the Buccaneers vs. 49ers odds, and make our expert NFL picks and predictions.

The Bucs made easy work of the Tennessee Titans in a 20-6 victory Sunday. They covered as 2.5-point favorites and the Under 38.5 was never in danger. Tampa sits in 2nd place in the NFC South, and the Bucs are just 1 game behind the New Orleans Saints.

The 49ers are tied atop the NFC West with the Seattle Seahawks. The Niners pulverized the Jacksonville Jaguars 34-3 last week. They covered as 3-point favorites, and the Under 44.5 cashed with the Jags' ineptitude on offense.

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Buccaneers at 49ers odds

Provided by BetMGM Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:13 p.m. ET.

Moneyline (ML): Buccaneers +525 (bet $100 to win $525) | 49ers -750 (bet $750 to win $100)
Against the spread (ATS): Buccaneers +13 (-110) | 49ers -13 (-110)
Over/Under (O/U): 41.5 (O: -110 | U: -110)

Buccaneers at 49ers key injuries

Buccaneers

S Ryan Neal (thumb) out
LB Devin White (foot) questionable

49ers

OG Aaron Banks (toe) out

Buccaneers at 49ers picks and predictions

Prediction

49ers 31, Buccaneers 17

Moneyline

The 49ers are heavy favorites, and for good reason. There's no chance we're going to take this ML. However, our handicapper John Holler has an enticing prop bet on RB Christian McCaffrey's total rushing yards in his weekly 5 best prop bets post.

Against the spread

The Niners are 3-1 ATS at home this year, but Tampa is 4-0 on the road and 6-3 overall. Other than playing the Philadelphia Eagles in Week 3, a game they didn't cover, the Bucs really have had a soft schedule. So I'm not buying into that data.

Take the 49ERS -13 (110).

Over/Under

Tampa is just 2-8 O/U this year, and the 49ers are 4-5-1. Again, the Bucs have had a pretty weak schedule and are tied for 22nd at 19.8 points per game. The Niners are 3rd with 28 points per game. I like the Over here because I think San Francisco is good for at least 30 of it. If the Bucs can muster something to avoid getting shut out, the OVER 41.5 (-110) looks good.

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