San Francisco 49ers at Seattle Seahawks odds, picks and predictions

Kevin Erickson | Staff Writer

The San Francisco 49ers (7-3) and Seattle Seahawks (6-4) play on Thanksgiving night for a Week 12 matchup. Kickoff is scheduled for 8:20 p.m. ET (NBC). Below, we analyze FanDuel Sportsbook's lines around the 49ers vs. Seahawks odds, and make our expert NFL picks and predictions.

The 49ers are coming off a 27-14 victory against the Tampa Bay Buccaneers last Sunday, and it polished off the Jacksonville Jaguars 34-3 in the prior game as a 3-point favorite on the road. The Under has cashed in 2 straight, and 3 of the past 4 contests.

Against the NFC West, San Francisco is 2-0 straight up (SU) and 1-1 against the spread (ATS), cashing the Over in both divisional games.

The Seahawks are coming off a 17-16 loss against the Los Angeles Rams at SoFi Stadium, while losing 2 of the past 3 games overall. Seattle did cover the 1.5-point spread, snapping an 0-4-1 ATS slide. The Under has cashed in 5 of the past 7 games overall.

Seattle is 1-2 SU in 3 games inside the division, while going 1-1-1 ATS, while cashing the Under in all 3 outings.

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49ers at Seahawks odds

Provided by FanDuel Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 9:56 p.m. ET.

Moneyline (ML): 49ers -335 (bet $335 to win $100) | Seahawks +270 (bet $100 to win $270)
Against the spread (ATS): 49ers -7 (-115) | Seahawks +7 (-105)
Over/Under (O/U): 43.5 (O: -115 | U: -105)

49ers at Seahawks key injuries

49ers

OG Aaron Banks (toe) questionable
DE Robert Beal (hamstring) questionable
OG Spencer Burford (knee) questionable
CB Samuel Womack (knee) questionable

Seahawks

OT Abraham Lucas (knee) questionable
S Jerrick Reed II (knee) out
QB Geno Smith (elbow) questionable
RB Kenneth Walker III (oblique) doubtful
WR Dareke Young (abdomen) doubtful

49ers at Seahawks picks and predictions

Prediction

49ers 29, Seahawks 13

Moneyline

The 49ers (-335) will cost you more than 3 times your potential return, and that's way too risky for this Thanksgiving night battle on the road. Even if San Francisco was home, it would be too much risk for a singular bet.

AVOID, and look to the spread instead.

Against the spread

The 49ERS -7 (-115) are a better value laying the points, even on the road.

The Seahawks +7 (-105) are quite banged up. Walker carrying a doubtful tag is bad news, as RB Zach Charbonnet is likely to carry the mail. Smith is also 50-50 to play, and if QB Drew Lock is given the keys to the car, San Francisco wins this game going away. Even with Smith in there, no Walker makes the Niners a solid play.

Over/Under

UNDER 43.5 (-105) is a decent play, and hopefully you'll be able to see it before the tryptophan kicks in.

The Under has cashed in 5 of the past 7 games for the Seahawks, including all 3 games inside the NFC West Division this season.

The Under has cashed in the past 2 games for the 49ers, while going 3-1 in the past 4 outings. Look for the total to go low, especially since Seattle will have less effectiveness in the run game, and if Smith is out, even worse.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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