Los Angeles Rams at Arizona Cardinals odds, picks and predictions

Jess Root | Staff Writer

The Los Angeles Rams (4-6) are on the road to face the Arizona Cardinals (2-9) in a rematch of their Week 6 matchup. Kickoff is Sunday at 4:05 p.m. ET at State Farm Stadium (FOX). Below, we analyze FanDuel Sportsbook's lines around the Rams vs. Cardinals odds, and make our expert NFL picks and predictions.

The Rams are coming off a 17-16 home win over the Seattle Seahawks, but they did not cover the 1.5-point spread as home favorites. The win snapped a 3-game losing streak.

The Cardinals lost last week 21-16 to the Houston Texans, covering the 5.5-point spread as underdogs. The Cardinals are 1-1 straight up and 2-0 ATS since the return of QB Kyler Murray.

FOOTBALL NEVER STOPS

Live games, analysis and more 7 days a week: Get ESPN+

Rams at Cardinals odds

Provided by FanDuel Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:45 p.m. ET.

Moneyline (ML): Rams -132 (bet $132 to win $100) | Cardinals +112 (bet $100 to win $112)
Against the spread (ATS): Rams -2.5 (-110) | Cardinals +2.5 (-110)
Over/Under (O/U): 45.5 (O: -106 | U: -114)

Rams at Cardinals key injuries

Rams

S Quentin Lake (hamstring) out
WR Ben Skowronek (hip) questionable

Cardinals

WR Marquise Brown (heel) questionable
RB Emari Demercado (toe) questionable
CB Antonio Hamilton (groin) out
DL Jonathan Ledbetter (shoulder) questionable
WR Zach Pascal (hamstring) questionable
DL Kevin Strong (knee) out
WR Michael Wilson (shoulder) out

Rams at Cardinals picks and predictions

Prediction

Cardinals 24, Rams 23

Moneyline

The Cardinals have been in position to win the game in their final possession in consecutive games since Murray's return, getting a game-winning field goal against the Falcons and failing to score a game-winning touchdown last week in Houston.

The Cardinals have not beaten the Rams in Arizona since 2014 and are 2-12 against them since Sean McVay became their head coach.

But the last time the Cardinals played the Rams, they didn't have RB James Conner, S Jalen Thompson, S Budda Baker or QB Kyler Murray.

The Cardinals' 2 wins this season are at home and have averaged 25 points per game at home.

BET CARDINALS (+112).

Against the spread

The Cardinals are 2-0 ATS since Murray's return and 4-1 ATS at home this season.

The Rams are 0-4 ATS in their last 4 games. QB Matthew Stafford has turned the ball over in 3 straight games.

You could take the Cardinals to cover, but with plus odds on the moneyline, make your bet there.

PASS.

Over/Under

The Over is 5-0 in the Cardinals' 5 home games this season.

The Under is 5-1 in the Rams' last 6 games.

The Cardinals have scored no fewer than 20 points at home this season and scored 24 or more in 4 of 5 home games.

They have played in 1-score games in 3 of their last 4 games.

BET OVER 45.5 (-106).

Play our free daily Pick’em Challenge and win! Play now!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

Facebook Twitter Email