San Francisco 49ers at Philadelphia Eagles odds, picks and predictions

Payton Shanks | Staff Writer

The San Francisco 49ers (8-3) and Philadelphia Eagles (10-1) meet in a rematch of last season's NFC Championship Game Sunday. Kickoff from Lincoln Financial Field is set for 4:25 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook's lines around the 49ers vs. Eagles odds, and make our expert NFL picks and predictions.

San Francisco has now won 3 straight games after routing the Seattle Seahawks 31-13 Nov. 23. The 49ers covered as 7-point favorites in the win and now have won each of their last 3 by at least 2 scores. San Francisco has scored 27 or more points in each of its wins during this current streak and has not allowed more than 14 points in any game during that same span.

Philadelphia came away with a 37-34 OT win over the Buffalo Bills last Sunday as a 3-point favorite. QB Jalen Hurts completed only 18 of his 31 passes for 200 yards, but accounted for 5 total TDs and threw only 1 INT in the win. Hurts threw 2 TDs in the 4th quarter to keep Philly in the game, and scored the game-winning rushing TD in overtime to keep Philly undefeated at home.

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49ers at Eagles odds

Provided by BetMGM Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 3:44 p.m. ET.

Moneyline (ML): 49ers -155 (bet $155 to win $100) | Eagles +130 (bet $100 to win $130)
Against the spread (ATS): 49ers -3 (-110) | Eagles +3 (-110)
Over/Under (O/U): 48 (O: -110 | U: -110)

49ers at Eagles key injuries

49ers

DE Arik Armstead (foot) questionable
RB Jordan Mason (hamstring) questionable
WR Ray-Ray McCloud (rib) questionable

Eagles

TE Grant Calcaterra (ankle) questionable
DT Fletcher Cox (groin) questionable
LB Zach Cunningham (hamstring) out
S Justin Evans (knee) out
TE Dallas Goedert (forearm) doubtful

49ers at Eagles picks and predictions

Prediction

49ers 23, Eagles 21

Moneyline

LEAN 49ERS (-155).

Philadelphia has been very hot this season and is the hotter team as it has only lost 1 game, but the 49ers seem to have the edge here. San Francisco has looked dominant on both sides of the ball when fully healthy, especially since the addition of DE Chase Young. The 49ers have now won 3 straight by double digits, while the Eagles have had 4 consecutive 1-possession games.

Against the spread

BET EAGLES +3 (-110).

The Eagles are 7-3 ATS in their last 10 matchups with San Francisco and are 2-0-1 ATS in their last 3 games overall. Philadelphia is also 2-0-1 ATS in its last 3 home games. The 49ers are also only 2-4 ATS in their last 6 overall. This will be a very even contest, and Philadelphia's home field advantage will help the Eagles cover here.

Over/Under

LEAN UNDER 48 (-110).

The Under has hit in 2 of San Francisco's last 3 games overall and has hit in 5 consecutive 49ers-Eagles matchups. Both teams are very good defensively, especially in the run game. Since neither team will have much success on the ground, offensive production will be harder to come by for both sides and will make the Under a safe bet here.

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