First look: San Francisco 49ers at Arizona Cardinals odds and lines

Jess Root | Staff Writer

The San Francisco 49ers (10-3) are on the road in Week 15 to face the Arizona Cardinals (3-10) for the 2nd time this season. Kickoff is Sunday at 4:05 p.m. ET at State Farm Stadium (CBS). Below, we look at 49ers vs. Cardinals odds from BetMGM Sportsbook. Also see: SportsbookWire's NFL picks and predictions.

The 49ers took over the No. 1 seed in the NFC over the weekend. They beat the Seattle Seahawks 28-16 at home, but failed to cover the 16.5-point spread as favorites. It was their 5th consecutive win.

The Cardinals were on their bye in Week 14. They picked up their 3rd win of the season in Week 13 with a 24-10 road win over the Pittsburgh Steelers as 6-point underdogs. It was their 1st road win since Week 10 of 2022.

FOOTBALL NEVER STOPS

Live games, analysis and more 7 days a week: Get ESPN+

49ers at Cardinals odds

Provided by BetMGM Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 6:43 a.m. ET.

Moneyline (ML): 49ers -800 (bet $800 to win $100) | Cardinals +550 (bet $100 to win $550)
Against the spread (ATS): 49ers -13.5 (-110) | Cardinals +13.5 (-110)
Over/Under (O/U): 46.5 (O: -110 | U: -110)

2023 betting stats

ML: 49ers 10-3 | Cardinals 3-10
ATS: 49ers 7-6 | Cardinals 7-5-1
O/U: 49ers 6-6-1 | Cardinals 7-6

49ers vs. Cardinals head-to-head

Dating back to 1951, the 49ers lead the all-time series 35-29 and have won the last 3 meetings.

QB Brock Purdy is 3-0 in 3 career starts against the Cardinals. He has a passer rating of 146.0. He had only 1 incompletion in 21 passing attempts in the 35-16 Niners win at home over the Cardinals in Week 4. In that game, RB Christian McCaffrey had 177 total yards and 3 TDs.

Cardinals QB Kyler Murray has missed the last 4 games between the 2 teams. He is 2-5 against the Niners, but won the last meeting in which he played, a 17-10 home win in October 2021.

Play our free daily Pick’em Challenge and win! Play now!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

Facebook Twitter Email