Dallas Cowboys at Buffalo Bills odds, picks and predictions

Ryan Dodson | Staff Writer

The Dallas Cowboys (10-3) and Buffalo Bills (7-6) meet Sunday afternoon at Highmark Stadium. Kickoff is scheduled for 4:25 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook's lines around the Cowboys vs. Bills odds, and make our expert NFL picks and predictions.

The Cowboys covered as 4.5-point favorites in a 33-13 convincing win against the Philadelphia Eagles last week. The Under 52.5 cashed. QB Dak Prescott was 24-for-39 for 271 yards, 2 TDs and no INTs as he added to his MVP resume. He hasn't thrown an interception in 4 straight games.

The Bills covered as 1.5-point underdogs in a 20-17 victory over the Kansas City Chiefs. The Under 49 was never in jeopardy in a game the Chiefs probably lost rather than the Bills winning. QB Josh Allen was 23-for-42 for 233 yards, 1 TD and 1 INT. He has thrown at least 1 pick in 9 straight games.

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Cowboys at Bills odds

Provided by BetMGM Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1:02 p.m. ET.

Moneyline (ML): Cowboys +110 (bet $100 to win $110) | Bills -130 (bet $130 to win $100)
Against the spread (ATS): Cowboys +2 (-110) | Bills -2 (-110)
Over/Under (O/U): 49.5 (O: -110 | U: -110)

Cowboys at Bills key injuries

Cowboys

WR Brandin Cooks (illness) questionable
CB Stephon Gilmore (illness) questionable
S Malik Hooker (ankle) questionable
C Billy Price (undisclosed) out

Bills

DE A.J. Epenesa (ribs) out
S Micah Hyde (neck) out

Cowboys at Bills picks and predictions

Prediction

Bills 24, Cowboys 17

Moneyline

It's supposed to be a rainy Sunday afternoon, which definitely benefits Buffalo. The Bills are also 5-1 at home, while Dallas is 3-3 on the road. I look for a grind-it-out style of game in wet conditions, which benefits the home side. You can take the BILLS -130, but it would make more sense to look to the spread.

Against the spread

Unless you feel like the Bills won't win by more than a couple, BILLS -2 (-110) is cheaper than the ML. The Bills have won 2 straight against Dallas. The Cowboys rely heavily on the passing game at 2nd in the league with 262.8 passing yards per game. If it's raining, that really stunts their offense.

Over/Under

Due to the conditions, I look toward the Under here. The Bills are just 3-7 O/U in the last 10. The ground game will be heavily utilized, which will run the clock. The Under has cashed in the last 2 meetings between the sides as well.

Take the UNDER 49.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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