San Francisco 49ers at Arizona Cardinals odds, picks and predictions

Jess Root | Staff Writer

The San Francisco 49ers (10-3) and Arizona Cardinals (3-10) meet Sunday at State Farm Stadium. Kickoff is set for 4:05 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook's lines around the 49ers vs. Cardinals odds, and make our expert NFL picks and predictions.

The 49ers have won 5 straight games and are currently the No. 1 seed in the NFC. They beat the Seattle Seahawks 28-16 in Week 14 but did not cover the 16.5-point spread as home favorites.

The Cardinals had their bye in Week 14. Their last game was a 24-10 road win over the Pittsburgh Steelers in Week 13 as 6-point underdogs.

The 49ers won the Week 4 meeting 35-16 in Santa Clara.

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49ers at Cardinals odds

Provided by BetMGM Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1:21 p.m. ET.

Moneyline (ML): 49ers -800 (bet $800 to win $100) | Cardinals +550 (bet $100 to win $550)
Against the spread (ATS): 49ers -12.5 (-105) | Cardinals +12.5 (-115)
Over/Under (O/U): 48.5 (O: -110 | U: -110)

49ers at Cardinals key injuries

49ers

DL Arik Armstead (foot, knee) out
OL Aaron Banks (hip) questionable
OL Spencer Burford (knee) questionable
LB Oren Burks (knee) out
TE Ross Dwelley (ankle) out
LB Dre Greenlaw (hip, ankle) probable
DL Javon Hargrave (hamstring) out
RB Elijah Mitchell (knee) out
CB Charvarius Ward (groin) questionable

Cardinals

LB Krys Barnes (ribs) questionable
WR Marquise Brown (heel) questionable
RB Emari Demercado (neck) available
TE Geoff Swaim (back) questionable
OL Elijah Wilkinson (neck) questionable
WR Michael Wilson (shoulder) questionable

49ers at Cardinals picks and predictions

Prediction

49ers 31, Cardinals 20

Moneyline

The 49ers (-800) have won 5 straight games. The Cardinals have not won consecutive games all season.

Arizona had no answer for the 49ers offense in Week 4 when they gave up 5 touchdowns, 3 of them to RB Christian McCaffrey.

The 49ers have won the last 3 meetings, but there is no reason to bet the moneyline at -800.

PASS.

Against the spread

With 3 front-7 defensive starters out and with Cardinals QB Kyler Murray playing in this game, the Cardinals should be able to move the ball and at least be competitive. RB James Conner had 105 yards and 2 TDs in the Cardinals' win over the Steelers.

But the Cardinals' defense will not be able to slow the San Francisco offense, which has scored 27 or more points in 5 straight games.

The Cardinals have not scored more than 25 points in their last 10 games.

BET CARDINALS +12.5 (-115).

Over/Under

The 49ers should crack 30 points this week.

The Cardinals have scored 24 and 25 points in wins since Murray's return to the lineup.

The total was 51 in their Week 4 matchup.

BET OVER 48.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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