First look: Buffalo Bills at Los Angeles Chargers odds and lines

Payton Shanks | Staff Writer

The Buffalo Bills (8-6) pay a visit to the Los Angeles Chargers (5-9) Saturday. Kickoff from SoFi Stadium is set for 8 p.m. ET (Peacock). Below, we look at Bills vs. Chargers odds from FanDuel Sportsbook. Also see: SportsbookWire's NFL picks and predictions.

Buffalo has back-to-back wins after routing the Dallas Cowboys 31-10 Sunday while covering as a 2.5-point underdog. Buffalo's run game and defense dominated as the Bills racked up 266 yards on the ground and held the Cowboys to 195 total yards.

Los Angeles (+3) was routed 63-21 by the Las Vegas Raiders Thursday. After the loss the Chargers parted ways with coach Brandon Staley and general manager Tom Telesco. The Chargers have lost back-to-back games and 5 of their last 6.

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Bills at Chargers odds

Provided by FanDuel Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 11:10 p.m. ET.

Moneyline (ML): Bills -850 (bet $850 to win $100) | Chargers +590 (bet $100 to win $590)
Against the spread (ATS): Bills -13.5 (-110) | Chargers +13.5 (-110)
Over/Under (O/U): 42.5 (O: -110 | U: -110)

2023 betting stats

ML: Bills 8-6 | Chargers 5-9
ATS: Bills 6-8 | Chargers 5-9
O/U: Bills 4-10 | Chargers 4-10

Bills vs. Chargers head-to-head

Los Angeles leads the all-time series 25-13-2 and is 4-1 in the last 5 meetings with Buffalo. The Chargers and Bills have not met since 2020 when the Bills picked up a 27-17 win in Buffalo. Los Angeles has scored 30 or more in 3 of its last 4 wins vs. Buffalo.

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