Buffalo Bills at Los Angeles Chargers odds, picks and predictions

Seth Orlemann | Staff Writer

The Buffalo Bills (8-6) visit the Los Angeles Chargers (5-9) Saturday. Kick from SoFi Stadium is scheduled for 8 p.m. ET (Peacock). Below, we analyze BetMGM Sportsbook's lines around the Bills vs. Chargers odds, and make our expert NFL picks and predictions.

The Bills have won in back-to-back weeks after a dominant 31-10 victory over the Dallas Cowboys to cover as 2.5-point home favorites Sunday. QB Josh Allen went 7 of 15 for 94 yards with a TD and added 8 carries for 24 yards and a TD on the ground. RB James Cook carried the ball 25 times for 179 yards and a TD on the ground while hauling in 2 receptions for 42 yards and a TD through the air.

The Chargers have lost back-to-back games after failing to cover as 3-point underdogs in a 63-21 loss at the Las Vegas Raiders Dec. 14. QB Easton Stick went 23 of 32 for 257 yards with 3 TDs and an interception. His top receiver was WR Joshua Palmer, who had 4 receptions for 113 yards and a TD. On the ground, RB Isaiah Spiller carried the ball 16 times for 50 yards.

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Bills at Chargers odds

Provided by BetMGM Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 10:55 a.m. ET.

Moneyline (ML): Bills -800 (bet $800 to win $100) | Chargers +550 (bet $100 to win $550)
Against the spread (ATS): Bills -12.5 (-110) | Chargers +12.5 (-110)
Over/Under (O/U): 44 (O: -110 | U: -110)

Bills at Chargers key injuries

Bills

DE A.J. Epenesa (rib) doubtful
S Micah Hyde (neck) doubtful
WR Justin Shorter (hamstring) out

Chargers

WR Keenan Allen (heel) out
CB Essang Bassey (concussion) questionable
DE Joey Bosa (foot) out
CB Deane Leonard (heel) doubtful
DT Nick Williams (shoulder) questionable

Bills at Chargers picks and predictions

Prediction

Bills 31, Chargers 17

Moneyline

PASS.

The Bills (-800) have no value to win at this price over a Chargers team that is falling apart at the seams due to injuries.

Against the spread

LEAN BILLS -12.5 (-110).

Buffalo is hitting its stride while Los Angeles is falling apart, which will make the perfect storm for a dominant Bills victory. Buffalo has won 3 of 4, winning by an average margin of 16.7 points per game in those victories. It has scored at least 31 points in 3 of its last 4 games, while the Chargers have scored 10 or fewer in 3 of their last 4.

Over/Under

BET OVER 44 (-110).

Stick performed well enough for the Chargers last week with over 250 yards passing and 3 TDs. While his performance this week may not be enough to keep Los Angeles in the game, putting points on the board will aid the Over. Buffalo will be forced to carry a majority of the load, which it will do with Allen, Cook, and WR Stefon Diggs. Expect a strong performance from the Bills offense.

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