NFC Divisional Round: Green Bay Packers at San Francisco 49ers odds, picks and predictions

Seth Orlemann | Staff Writer

The Green Bay Packers (10-8) visit the San Francisco 49ers (12-5) on Saturday in the NFC Divisional Round. Kick from Levi's Stadium is scheduled for 8:15 p.m. ET (FOX). Below, we analyze FanDuel Sportsbook's lines around the Packers vs. 49ers odds, and make our expert NFL picks and predictions.

The Packers shocked the world with a 48-32 thrashing over the Cowboys, who were previously undefeated at home, in the Wild Card Round while covering as 7-point road underdogs. They ended their season winning 5 of their final 7 games, including their last 2 and have won 4 of their last 5 on the road. QB Jordan Love finished the regular season with 32 touchdowns, good for 2nd in the NFL, and 11 interceptions.

San Francisco earned a 1st-round bye after finishing as the top seed in the NFC. It won 7 of its final 9 games while dropping 2 of its final 3. QB Brock Purdy ended the season with 31 TDs, good for 3rd, and 11 INTs. He finished 5th in passing yards with 4,280 and 1st in the NFL with a 72.7 QBR. RB Christian McCaffrey finished 1st in the NFL in rushing yards with 1,459 and 4th in rushing TDs with 14. He averaged a career-high 5.4 yards per carry on 272 total carries.

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Packers at 49ers odds

Provided by FanDuel Sportsbook; access Paste BN Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:10 a.m. ET.

Moneyline (ML): Packers +390 (bet $100 to win $390) | 49ers -510 (bet $510 to win $100)
Against the spread (ATS): Packers +10 (-108) | 49ers -10 (-112)
Over/Under (O/U): 50.5 (O: -115 | U: -105)

Packers at 49ers key injuries

Packers

CB Jaire Alexander (shoulder, ankle) questionable
RB AJ Dillon (thumb, neck) questionable
P Daniel Whelan (illness) questionable

49ers

LB Dre Greenlaw (Achilles) questionable

Packers at 49ers picks and predictions

Prediction

49ers 38, Packers 24

Moneyline

PASS.

At -510, there is no value betting on the 49ers, who are rightful heavy favorites, to beat the Packers, who were 5-5 on the road this season.

Against the spread

BET 49ERS -10 (-112).

The Packers found success last week by exposing Dallas' run defense. Against a top-ranked San Francisco defense, they will not find the same amount of success. The Niners ranked 7th in the NFL this season allowing 303.9 yards per game, 3rd in opponent points per game (17.5), and 2nd in opponent TDs per game (1.8). On the offensive side of the ball, while the Packers have a solid defense, the Niners ranked 2nd in PPG (28.9), 1st in YPG (398.4) and 1st in yards per play (6.6).

While the Packers dominated the Cowboys, do not expect the same result come Saturday night. McCaffrey and the San Francisco offense are too versatile and will have their way with Green Bay.

Over/Under

BET OVER 50.5 (-115).

The Packers have hit the Over in 11 of their 18 games this season, including last week's victory over Dallas, while the 49ers have a 9-7-1 Over record. Green Bay hit the Over in 7 of its last 8 games and scored 33 points or more in 3 of its last 4. San Francisco hit the Over in 3 of its last 4 while scoring 27 or more in 7 of its last 9.

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